Longevity News and Review with Dr. Goldman & Dr. Kltaz

By Dr. Robert Goldman
For The Bali Times

American Academy of Anti-Aging MedicineLongevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 20,000 physician and scientist members from 90 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.  Dr. Ronald Klatz, A4M president, and Dr. Robert Goldman, A4M chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their commentary.

Human Skin Cells Reprogrammed to Act like Stem Cells

Two separate teams, one from the University of Wisconsin-Madison and the other from Kyoto University, reported that they had successfully reprogrammed human skin cells to act like embryonic stem cells. The University of Wisconsin team, led by James Thomson (who first developed the initial human embryonic stem cell line almost 10 years ago), employed somatic cell nuclear transfer to use four factors to reprogram human skin (somatic) cells to pluripotent stem cells. In the Kyoto University work, Shinya Yamanaka and colleagues inserted four genes into human skin cells to reprogram them into “induced pluripotent cells,” which look and act like stem cells.

Dr Klatz remarks: This is a pair of landmark advancements that circumvents a number of ethical and practical obstacles to stem cell therapeutics. These researchers have identified a potentially abundant source of stem cells for therapeutics that can treat a wide variety of aging-related disorders.

Cancer Risks of a Carb-Related Carcinogenx

Increased dietary intake of acrylamide, a carcinogen created when starchy (carbohydrate-rich) foods are baked, roasted, fried or toasted may raise the risk of endometrial cancer by 29 percent, and ovarian cancer by 78 percent. Janneke Hogervorst and colleagues from Maastricht University analyzed data from more than 62,000 women in the Netherlands for a 11.3-year period. Where the average acrylamide intake was 8.9 mcg per day, the highest intake, at 40.2 mcg per day, was associated with the greatest increases in risks of both endometrial and ovarian cancers. Dr. Hogervorst’s team found that the risks were even more pronounced in people with no history of smoking, where the highest acrylamide intakes were associated with a 99-percent increase in risk of endometrial cancer and 122-percent increase in risk of ovarian cancer.

Dr. GoldmanDr. Goldman observes: This is one of a few long-term human studies that correlates dietary factors to increased cancer risks. Acrylamide first made headlines five years ago when scientists at the Swedish Food Administration reported that high levels of acrylamide caused cancer in laboratory animals. Since then, animal studies continue to show the risks associated with the compound. This observational study points to the importance of making prudent dietary choices, to reduce or eliminate one’s consumption of highly processed carbohydrates.

Bulky Biceps, Trim Waist Correlate to Longevity in Men

The size of a man’s waistline and the muscle mass of his biceps provide s snapshot of mortality risk in aging men. S. Goya Wannamethee and colleagues from Royal Free and University College Medical School in London studied more than 4,100 men ages 60 to 79, and found that those with a waist circumference less than 40 inches and above-average muscle mass in their upper arms were up to 36 percent less likely to die over a six-year period (as compared to those with bigger waists and smaller arm muscles). The researchers also found the combination of waist size and arm muscle mass to provide a far more accurate gauge of death risk as compared to body mass index (BMI) measurements, which the team found was linked to mortality only among very thin men.

Comments Dr. Klatz: These findings emphasize the role of life-long fitness in longevity. Fitness is a key element in the anti-aging lifestyle, and men who choose this lifestyle can indeed live longer and better lives.

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