Longevity News and Review with Dr. Goldman & Dr. Kltaz

By Dr. Robert Goldman
For The Bali Times

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 20,000 physician and scientist members from 90 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.  Dr. Ronald Klatz, A4M president, and Dr. Robert Goldman, chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their commentary


Omega-3 Cuts Brain Plaque Buildup Characteristic of Alzheimer’s Disease

Greg Cole and colleagues from the University of California/Los Angeles (UCLA) have shown that docosahexaenoic acid (DHA), a type of omega-3 fatty acid, cuts the buildup of plaques from beta-amyloid deposits that are associated with brain cell damage and the onset of Alzheimer’s Disease (AD). Specifically, the researchers found that DHA boosts production of a protein, LR11, that is known to destroy the brain plaques characteristic of AD. The team found that the protective effects of DHA on LR11 persisted in models of cells from mice, rats, and human brain cells. The researchers encourage the intake of supplemental fish oil (one of the most potent sources of omega-3s) as a interventive measure at the earliest stages of the onset of Alzheimer’s.

Dr. Klatz remarks: Currently, about 12 million people in the United States and Europe suffer from Alzheimers. Some projections estimate that number will triple by 2050. Consequently, the discovery and/or further substantiation of simple and effective natural, non-drug approaches that may counter the biological mechanisms behind the disease will become increasingly important in the coming decades.

Wine Polyphenols Combat Effect of Fatty Foods

Joseph Kanner from Volcani Center (Israel) and colleagues have discovered that red wine polyphenols mitigate the levels of a byproduct of fat digestion that is known to increase the risk of cardiovascular disease and other conditions. In their study, the researchers identified that red wine polyphenols prevented the production and build-up of malondialdehyde (MDA) in the blood. The team reported that: “Our study suggests that red wine polyphenols exert a beneficial effect by [this] novel function – absorption inhibition.”

dr. goldmanDr. Goldman observes: This study continues a line of recent and exciting studies correlating a multitude of health benefits with red wine. Resveratrol, a compound that is found in the skin of red grapes and is a constituent of red wine, has been associated with a number of anti-inflammatory, anti-viral, and neuroprotective effects, This study’s identification of the role of red wine polyphenols in reducing fat digestion byproducts could serve to help explain the “French paradox” that the incidence of coronary heart disease is relatively low in southern France and the Mediterranean countries despite high dietary intake of saturated fats.

Combatting Fatigue and Improving Mental Function in the Very Old

As we age, our natural levels of L-carnitine drops; yet L-carnitine is necessary to help cells to produce energy from fat. As a result, many older people suffer from weakness, impaired mobility, poor endurance, and declining mental health. Mariano Malaguarnera and colleagues from the University of Catania, Italy, report that L-carnitine, an amino acid available as a nutritional supplement, can lessen fatigue and boost mental function in the very old. In a group of people age 100 and over, the Italian researchers found that L-carnitine supplementation reduced cholesterol levels, boosted muscle mass, and reduced fat mass. Those taking the supplement also reported significant reductions in mental, physical, and overall fatigue. They scored higher on a test of mental function, and were able to walk significantly farther than those who did not take the supplement. L-carnitine supplementation was well tolerated by the study subjects, with no serious side-effects.

Dr. Klatz comments: L-carnitine levels reach a lifetime low starting at age 70, which may contribute to many of the common complaints of aging – weakness and lack of endurance, mobility issues, poor memory and attention ,etc. This study is a striking demonstration of a simple, natural, and safe approach to curb these aging-related issues.

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