Longevity News & Review

By Robert Goldman
For The Bali Times

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 20,000 physician and scientist members from 90 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, A4M president, and Dr. Robert Goldman, A4M chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their commentary

Testosterone Replacement Benefits Older Men, Reducing Cardiovascular Disease and Diabetes Risk Factors
Testosterone deficiency is an age-related condition, affecting 18 percent or more of men as of age 70. Farid Saad, an investigator from Berlin, Germany, and colleagues, found that testosterone replacement therapy (TRT) in older men with waning testosterone levels improves the risk factors for cardiovascular disease and diabetes. In the first of two studies, Saad and team found that testosterone treatment significantly reduced waist circumference, total cholesterol, LDL (“bad”) cholesterol, triglycerides, and body mass index; TRT also increased HDL (“good”) cholesterol. In the second study, the researchers found the oldest men had similar improvements in metabolic risk factors while on TRT. States the team: “We conclude that if elderly men have a deficiency of testosterone, it is worthwhile to treat them with testosterone.”

Dr Klatz remarks: Testosterone levels in men decrease gradually over time, due to factors such as reduced activity, nutritional deficiency, diabetes, and HGH deficiency. This phenomenon is sometimes referred to as andropause. By age 60, many men have less than half the level of testosterone as they did when they were in their teens. Testosterone replacement therapy (TRT) has a multitude noteworthy benefits, including to increase lean body mass, decrease fat mass, improve cholesterol profile, including to decrease “bad” cholesterol (LDL), reduce bone fractures, improve cognitive functions, including visual spatial perception, improve mood, including remission of depression, as well as to boost sexual performance. Seek the guidance of a qualified anti-aging physician, preferably one who has been certified by the American Board of Anti-Aging & Regenerative Medicine (ABAARM).

Healthy Lifestyle Promotes Extended Healthspan
In the latest studies to validate lifestyle and other modifiable factors to promote a long and healthy lifespan, Annie Britton, from the University College London (United Kingdom), and colleagues analyzed data from a 17-year study of 10,000 London civil service workers (average age of 44 at study’s start). At the start of the study, the workers were asked about their family’s social class and personal education level, to establish socioeconomic position; they were also surveyed about lifestyle habits and daily stress levels. Seventeen years later, 13 percent of the men, and 15 percent of the women, were found to be free of major illnesses and retained good physical and mental functioning. The researchers found that the odds of this successful aging depended somewhat on socioeconomic position, however lifestyle and stress were just as important. Men and women who ate a healthy diet, did not smoke, and exercised regularly were more likely to remain free of disease and disability. For men, social support at work, to buffer job stress, promoted better long-term health. For women, moderate alcohol consumption appeared beneficial.

Dr. Goldman observes: This study is interesting in that it provides large-scale data suggesting that lifestyle changes can lessen the effects of factors that are difficult to change, such as finances and occupation.

Lifestyle Can Alter Gene Activity
A study completed by Linda Mustelin, from the University of Helsinki (Finland), and colleagues has found that physical inactivity and acquired obesity can alter gene activity by impairing the expression of the genes which help cells to produce energy. In their study involving identical twins, the team found that lifestyle contributes to insulin resistance, and is a greater factor for diabetes and heart disease in obese people moreso than genetics. The team reports that: “Acquired poor physical fitness is associated with defective expression of the oxidative components in [fat] tissue mitochondria.”

Comments Dr. Klatz: This is yet the latest of studies underscoring the role of lifestyle, specifically physical activity, in both lifespan and healthspan. Suggesting that fitness may ovverride heredity factors in the onset of disease, this study provides strong motivation to encourage all adults to engage in regular aerobic activity.

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