Longevity News & Review

By Dr. Robert Goldman
For The Bali Times

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 22,000 physician and scientist members from 105 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their commentary.

In Men, Heart Health Promoted by Type of Omega-3
A number of studies have demonstrated a wide range of health benefits of omega-3 fatty acids, primarily as DHA (docohexaenoic acid) and EPA (eicosapentanoic acid). Darshan Kelley, from the US Department of Agriculture’s Agriculture Research Service, and colleagues have found that supplements of DHA may benefit cardiovascular health in men with elevated triglycerides (hypertriglyceridemia). The researchers gave 34 men (ages 39 to 66) with elevated triglycerides a daily supplement of DHA (3 grams daily) for a 45-day period. At the study’s conclusion, DHA supplementation lowered C-reactive protein (CRP) by 15 percent, lowered interleukin-6 (IL-6) by 23 percent and reduced the numbers of circulating white blood cells (neutrophils) by 11 percent. Additionally, an anti-inflammatory compound, matrix metalloproteinas-2, rose by 7 percent. The team concludes that: “DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition.”

Dr. Klatz observes: Hypertriglyceridemia is associated with an increased risk of hardening of the arteries (athersclerosis), a major risk factor for cardiovascular disease, the leading cause of death in the United States and Europe. This study suggests the potential for an accessible nutrient, already shown to provide numerous other health benefits, to have a specific therapeutic role in promoting cardiovascular health.

Cardiovascular Risk Linked to Progression of Alzheimer’s

Vascular factors including medical history (heart disease, stroke, diabetes and hypertension), smoking and prediagnosis blood lipid measurements (total cholesterol, high-density lipoprotein, low-density lipoprotein and triglycerides) may be predictors for progression of Alzheimer disease (AD). Yaakov Stern, from Columbia University Medical Center (New York, USA), and colleagues studied 156 men and women with AD (mean age of 83 years at diagnosis) for a mean period of 3.5 years. The team found that AD progressed at a significantly faster rate in study subjects with elevated total cholesterol, elevated LDL cholesterol, or personal history of diabetes. HDL cholesterol and triglycerides were not found to have an impact on cognitive decline. The researchers speculate that cholesterol affect AD progression via increased oxidative stress or neuroinflammatory responses that trigger amyloid plaque production in the brain. Diabetes could influence AD through inflammation or by contributing to plaque and tangle formation, they also explain.

Remarks Dr. Goldman: More than 26 million people worldwide were estimated to be living with Alzheimer’s disease in 2006; by 2050, AD will afflict more than 106 million people. This study identifies the potential role of higher prediagnosis total cholesterol, LDL levels and history of diabetes in accelerating cognitive decline in patients with AD. This study is important in that it provides further evidence for the role of vascular risk factors in the course of AD.

Anger and Hostility May Cause or Worsen Heart Disease
Suggestions that anger and hostility may promote heart trouble have largely been hearsay or rumors, but a new meta-analysis identifies an association between these negative emotions and coronary heart disease (CHD). Yoichi Chida and Andrew Steptoe, from the University College London (United Kingdom), analyzed data from 25 studies investigating CHD outcomes in initially healthy populations (71.606 study subjects) and 19 studies of patients with CHD (8,120 subjects). Overall, 28 percent of the studies in healthy populations and 26.3 percent of the studies in heart disease patients showed a harmful effect from anger and hostility. In the meta-analysis, anger and hostility were associated with a 19-percent increase in coronary heart disease events in previously healthy individuals, and a 24-percent increased risk of a poor prognosis in those with pre-existing heart disease. The association remained significant in men, but not in women. Conclude the team: “The current review suggests that anger and hostility are associated with CHD outcomes both in healthy and CHD populations.”

Comments Dr. Klatz: This study is interesting in that it affirms the long-rumored suspicion that anger and hostility may cause or worsen heart disease. While the study does not elucidate a causal relationship, it does provide strong data to encourage consideration of behavioral changes to promote heart health, much as diet and exercise are now widely accepted modifications in this arena.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your FREE subscription to The Anti-Aging News Journal.

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