Longevity News & Review

By Dr Robert Goldman
For The Bali Times

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 22,000 physician and scientist members from 105 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their commentary.

Elevated Insulin Levels Linked to Increased Prostate Cancer Risk

Men with fasting levels of insulin that are elevated but still within the normal range may be at increased risk of prostate cancer. Demetrius Albanes, from the National Cancer Institute (Maryland USA), and colleagues studied 100 men with incident prostate cancer and 400 age-matched controls within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in Finland. Higher insulin levels were associated primarily with the development of earlier stage disease; risk also was increased for participants in higher quartiles of the homeostasis model assessment of insulin resistance (HOMA-IR), which is a resistance index that is highly dependent on fasting insulin. The researchers warn that: “Elevated fasting levels of serum insulin (but not glucose) within the normal range appear to be associated with a higher risk of prostate cancer.”

Dr. Klatz observes: While the relationship between obesity/insulin resistance syndrome and prostate cancer risk requires further elucidation, this study provides strong evidence for an association between circulating insulin levels and prostate cancer risk that appears to be independent of relative weight. The key message of this study is that elevated insulin levels, even if still within the normal range, may increase the risk of prostate cancer.

Elevated Diastolic Blood Pressure Linked to Cognitive Problems

Diastolic blood pressure, represented by the bottom number in a blood pressure reading, is measured when your heart is at-rest. Georgios Tsivgoulis, from University of Alabama, and colleagues have found that elevated diastolic blood pressure appears to be associated with cognitive impairment in people 45 and older. In their study, involving 19,836 black and white individuals from REGARDS (Reasons for Geographic and Racial Differences in Stroke), each 10-point increase over 90 mm Hg was associated with a 7-percent greater risk of problems with cognition. The increased risk of cognitive impairment associated with elevated diastolic blood pressure remained after adjusting for several potential confounders, including demographic variables, environmental characteristics, cardiovascular risk factors, depressive symptoms and use of antihypertensive medications. The team posits that because elevated diastolic blood pressure can accelerate the normal atrophy of small cerebral arterioles, the process may lead to formation of ischemic white matter lesions, which could result in cognitive impairment. The researchers suggest that: “[I]t’s possible that by preventing or treating high blood pressure, we could potentially prevent cognitive impairment.”

Remarks Dr. Goldman: This is an important large-scale study that uncovers a potentially significant contributor to cognitive decline, offering yet another reason to keep blood pressure at a normal, healthy level.

Regular Tea Drinkers May Enjoy Younger Biological Age
Telomeres are the endcaps on chromosomes, and telomeric shortening is thought to govern the number of times a cell can divide. Ruth Chan and a team of Hong Kong-based researchers studied 976 Chinese men and 1,030 Chinese women, ages 65+, surveying their dietary habits via a food questionnaire. Overall, only tea consumption was associated with telomere length. The highest intakes of Chinese tea (black or green), at three cups or 750 millilitres per day, was associated with telomeres that were 4.6 kilobases longer than people who drank an average of a quarter of a cup a day. The researchers calculated that this average difference in the telomere length corresponds to “approximately a difference of 5 years of life,” and comment that “the antioxidative properties of tea and its constituent nutrients may protect telomeres from oxidative damage in the normal ageing process.”

Comments Dr. Klatz: Tea is rich in four polyphenols (antioxidants), namely epigallocatechin gallate (EGCG), epigallocatechin, epicatechin gallate and epicatechin. This study provides evidence of a potentially important interventive nutritional agent to beneficially impact one’s biological age at its most basic cellular level.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavours and to sign-up for your FREE subscription to The Anti-Aging News Journal.

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