Longevity News & Review

By Dr. Robert Goldman
For The Bali Times

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 22,000 physician and scientist members from 105 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

‘50 Active Years After 50’
A £50 million research initiative, aimed at giving people “50 Active Years After 50,” is being launched by the University of Leeds. Recognizing that improvements in healthcare, diet and lifestyle are helping us to live longer, the program addresses the issue of age-related cellular, tissue and organ degeneration that lead to reductions in quality of life and our ability to contribute to society. “50 Active Years After 50” is developing new medical devices and regenerative therapies, ensuring that people can continue to be as active during their second half century as they were in their first. The research will focus on those areas most affected as we age – our joints, spine, teeth, heart and circulation – developing new technologies for tissue engineering and regeneration, longer-lasting joint replacements and spinal interventions The program is expected to accelerate the translation of new discoveries into clinical practice. Over its first five years, it plans to develop ten new products and halve the time it takes to get new products to market.

Dr. Klatz observes: This big-budget British research initiative aims to significantly improve the quality of living in our second half-century. It reaffirms the basic tenet held by the A4M and our member physicians, that the course of the aging process is not inevitable and is indeed modifiable.

Olive Oil Compound Targets Alzheimer’s
In that ADDLs, soluble oligomers of amyloid-B1–42 peptide, are thought to be the primary toxin adversely affecting brain cells in Alzheimer’s Disease, William Roth, from Monell Chemical Senses Center (Pennsylvania, US), and colleagues completed a series of in vitro studies showing that oleocanthal, a natural compound found in extra-virgin olive oil, beneficially alters ADDL size, structure and activity. Small amounts of oleocanthal were effective in reducing the ability of toxic ADDLs to cells in the brain’s hippocampus region. Further studies also revealed that oleocanthal can protect nerve connections from structural damage caused by ADDLs.

Remarks Dr. Goldman: This new study is important because it demonstrates an interventive benefit of oleocanthal, a natural compound found in extra-virgin olive oil, to combat the neurotoxic brain proteins of Alzheimer’s. The findings herald an important potential therapeutic opportunity for immunotherapy-based treatments for Alzheimer’s Disease.

Chocolate May Reduce Artery Hardening
Previous studies have found that increased dietary intake of flavonoids, a type of antioxidant, may prevent coronary heart disease.  Maria Monagas, from the University of Barcelona (Spain), and colleagues completed a study assessing the effects of cocoa, an important source of of flavonoids, on atherosclerosis, which is considered to be a low-grade inflammatory disease. The researchers studied 42 men and women, average age 70 years, all of whom met standard diagnostic criteria to be considered at high risk for coronary heart disease. Study subjects either consumed either skim milk, or skim milk enhanced with a chocolate compound containing 495 milligrams of polyphenols, for a four-week period. At the end of the study period, blood levels of biomarkers of inflammatory molecules that play a role in the migration of white blood cells into the cells lining blood vessels (endothelium), namely soluble endothelium-derived adhesion molecules P-selectin and intercellular adhesion molecule-1, were significantly lower in the group that received cocoa plus milk (as compared to those who consumed milk alone). Additionally, the group that consumed cocoa plus milk saw reduced expression of adhesion proteins in white blood cells (monocytes). The team concludes that: “These results suggest that the intake of cocoa polyphenols may modulate inflammatory mediators in patients at high risk of cardiovascular disease. These anti-inflammatory effects may contribute to the overall benefits of cocoa consumption against atherosclerosis.”

Comments Dr. Klatz: This study identifies that the antioxidant-rich cocoa compound reduces the presence of inflammatory markers of atherosclerosis, serving to reaffirm previously published studies that suggest a potential therapeutic role for chocolate in heart disease.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment and reversal of age-related dysfunction, disorders and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavours and to sign up for your free subscription to the Longevity Magazine™ e-Journal.

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