January 1-7, 2010
Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 22,000 physician and scientist members from 105 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.
Pomegranate as an Anti-Prostate Cancer Food
More than half a million men worldwide are diagnosed with prostate cancer every year, with over 200,000 deaths resulting from the disease. In that the cytochrome P450 enzyme, CYP1B1, is an established target in prostate cancer chemoprevention, scientists are engaged in efforts to identify compounds that inhibit CYP1B1 activity and thus confer beneficial effects against prostate cancer development. Daneel Ferreira, from the University of Mississippi, and colleagues performed an in vitro experiment that found that two antioxidants present in pomegranates, the ellagitannin compounds of punicalagins and punicalins, exert potent capacities to inhibit CYP1B1.
Dr. Klatz observes: A rich source of antioxidants, pomegranate fruit compounds inhibit a liver enzyme and thus may confer beneficial effects against prostate cancer development. This is another exciting example of the potential therapeutic functionality of foods.
Exercise Slashes Odds of Early Death from Heart Disease
While a routine program of physical exercise has been shown to reduce the risk of premature death in people with coronary artery disease, Richard V. Milani, from the Ochsner Clinic Foundation (Louisiana), and colleagues evaluated the contributing role of psychosocial stress in influencing the effects of exercise training. The team followed 522 cardiac patients, including 53 who had high stress levels and 27 control patients who had high stress levels but who did not engage in cardiac rehabilitation. The study subjects were offered 12 weeks of exercise classes, where they did 10 minutes of warm-up, 30 to 40 minutes of aerobic exercise (walking, rowing, jogging or similar) and then a 10-minute cool-down stretch. The classes were given three times a week and subjects were also asked to engage in one to three exercise sessions a week on their own. The researchers found that the study subjects who became physically fitter were 60 percent less likely to die in the following six years. Exercise also helped reduce stress levels from 1-in-10 patients to fewer than 1-in-20, which lowered the death rate for stressed subjects by 20 percent.
Remarks Dr. Goldman: This study demonstrates that routine moderate exercise can reduce the risk of premature death in people with heart problems by up to 60 percent. It is yet the latest of studies to attest to the life-saving benefits of exercise.
Mobile Phones Hitched to Hip May Reduce Bone Density
Tolga Atay, from Suleyman Demirel University (Turkey), and colleagues studied the effects of electromagnetic waves emitted from mobile phones operating at a frequency of 900 to 1800 MHz on the bone mineral density of the pelvic bone area, a common location at which men carry their mobile phones. The researchers conducted dual X-ray absorptiometry to measure bone density at the upper rims of the pelvis (iliac wings) in 150 men, average age 32, who carried their mobile phones on their belts for an average of 15 hours a day, and were mobile phone users for an average of six years. They found that bone density was slightly reduced on the side of the pelvis where the men carried their phones. While the difference between the two sides was not statistically significant and did not approach bone-level density reductions seen in people with osteoporosis, the researchers caution that further bone weakening could occur with continued carrying at this location.
Comments Dr. Klatz: Turkish researchers discover reduced pelvic bone density in men who carry mobile phones clipped to pant belts, reminding us to use cautionary discretion in utilizing mobile phones on an everyday basis.
Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment and reversal of age-related dysfunction, disorders and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
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