January 15-21, 2010

By Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 22,000 physician and scientist members from 105 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Many Cancers in US Caused by Obesity
According to the American Institute for Cancer Research (AICR), approximately 100,500 cancers occurring in the US every year can be attributed to excess body fat, underscoring the central role that overweight and obesity are now understood to play both in the development of cancer and in cancer survivorship. According to AICR, the estimated number of cancers that are linked to excess body fat include: 49 percent of endometrial cancers (20,700 cases/year); 35 percent of esophageal cancers (5,800 cases/year); 28 percent of pancreatic cancers (11,900 cases/year); 24 percent of kidney cancers (13, 900 cases/year); 21 percent of gallbladder cancers (2,000 cases/year); 17 percent of breast cancers (33,000 cases/year); and 9 percent of colorectal cancers (13,200 cases/year). Laurence Kolonel, Deputy Director of the Cancer Research Center of Hawaii and AICR/WCRF expert panel member, observed that: “We now know that carrying excess body fat plays a central role in many of the most common cancers. And it’s clearer than ever that obesity’s impact is felt before, during and after cancer – it increases risk, makes treatment more difficult and shortens survival.”

Dr. Klatz observes: These new data from The American Institute for Cancer Research are sobering statistics on the number of cancers that are caused by obesity/overweight, reminding us of the vast health-promoting benefits of maintaining a healthy weight.

Eating Quickly Raises Weight-Gain Risk
Previously, studies have identified two peptides that signal satiety, namely peptide YY (PYY) and glucagon-like peptide (GLP-1).  While knowledge of the mechanisms involved in appetite control by PYY and GLP-1 has increased, postprandial (after meal) concentrations of appetite-regulating hormones have not yet been examined. Alexander Kokkinos, from Lake General Hospital (Athens, Greece), and colleagues studied 17 healthy adult male subjects, to whom the researchers gave a test meal consisting of 300 ml ice cream (675 kcal), consumed in random order on two different sessions by each subject where each meal took either five minutes or 30 minutes. The team found that the subjects who ate in 30 minutes had higher levels of both PYY and GLP-1, as compared to the participants who ate their meal in five minutes. Levels of ghrelin, a hormone that signals hunger, were not different between the two groups. The researchers conclude that: “Eating at a physiologically moderate pace leads to a more pronounced [satiety] gut peptide response than eating very fast.”

Remarks Dr. Goldman: This study by Greek researchers finds that eating foods quickly may blunt the response of hormones that signal satiety, which may cause overeating. It suggests a potential for future advancements in hormonal bases for appetite control and weight management.

How You Sleep Impacts What You Eat
Orfeu M. Buxton, from Harvard Medical School, and colleagues studied 542 male motor freight workers (average age 49 years), to ascertain how sleep adequacy and workplace experiences influence food choices. The researchers found that a lack of job strain and greater supervisor support were significantly associated with adequate sleep; and that the subject’s educational level, age and adequate sleep were significantly associated with at least two of the three healthful eating choices assessed. Concludes the team: “Adequate sleep is associated with more healthful food choices and may mediate the effects of workplace experiences. Thus, workplace health programmes should be responsive to workers’ sleep patterns.”

Comments Dr. Klatz: In that disturbances of the sleep process have been previously linked to weight issues, this study reaffirms the notion that people who get enough sleep make healthier food choices. Sleep is a restorative biological process and is often underestimated in importance to health and wellbeing.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment and reversal of age-related dysfunction, disorders and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavours and to sign up for your free subscription to the Longevity Magazine™ e-Journal.

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