Aug. 27-Sep. 2, 2010

By Dr Robert Goldman


Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 22,000 physician and scientist members from 105 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, and Dr Ronald Klatz, M.D., D.O., A4M President, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Higher ‘Good’ Cholesterol May Cut Cancer
In that epidemiologic studies suggest an inverse relationship between serum total cholesterol levels and incident cancer, Haseeb Jafri, from Tufts University School of Medicine (Massachusetts, US), and colleagues have previously reported that lower levels of LDL (low-density lipoprotein, “bad”) cholesterol are associated with a significantly higher risk of incident cancer. The team now finds that higher HDL (high-density lipoprotein, “good”) cholesterol levels associate with lower cancer risk. Conducting a meta-analysis of clinical trials involving lipids interventions, the team assessed data from 24 studies and found “a significant inverse association between baseline HDL-C levels and the rate of incident cancer,” which persisted despite adjustments for confounding factors, such as LDL cholesterol, age, body mass index, sex and smoking. Specifically, for each 10 mg/dL higher increment of HDL cholesterol, there was a 36-percent lower relative risk of incident cancer.

Dr. Klatz observes: This finding by Tufts University researchers that associates higher HDL (“good”) cholesterol with lower cancer risk reminds us that biomarkers can span across medical conditions, reinforcing the notion of the interconnectivity of the origins of disease.

Lifestyle Modifications May Slash Strokes 
Researchers involved in the Interstroke study, involving 22 countries, find that 10 leading risk factors may account for 90 percent of risk of stroke. Comparing the lifestyle of 3,000 stroke patients with a matched group of 3,000 healthy counterparts (serving as the control group), Martin J O’Donnell, from McMaster University (Ontario, Canada), and colleagues observed that high blood pressure, smoking, a fat stomach, poor diet and lack of exercise accounted for 80 percent of stroke cases. Five additional factors of diabetes, excess alcohol, stress and depression, heart disorders and the presence of apolipoproteins in the blood were found to account for 10 percent of additional stroke cases. Noting that many of the risk factors coincide with those linked to heart attack risk, the team concludes that: “Our findings suggest that 10 risk factors are associated with 90 percent of the risk of stroke. Targeted interventions that reduce blood pressure and smoking, and promote physical activity and a healthy diet, could substantially reduce the burden of stroke.”

Remarks Dr. Goldman: This large-scale study identifies 10 leading risk factors that may account for 90 percent of risk of stroke, providing essential knowledge to more readily identify patients at increased risk and subsequently take interventive action. 

Med Diet Boosts Heart-Health Marker
A key marker of cardiac autonomic dysfunction, reduced heart rate variability serves as a major risk factor for coronary artery disease as well. Jun Dai, from Indiana University, and colleagues studied sets of male twins, a total of 276 middle-aged men, assessing dietary habits and measuring heart rate variability by ECG. The researchers found that those subjects who closely adhered to a Mediterranean diet (rich in cereals, fruits, legumes and whole grains, fish and olive oil), had higher heart rate variability, as compared to those who did not follow that type of diet.

Comments Dr. Klatz: Men who enjoy a Mediterranean diet improve their measures of heart rate variability, and subsequently lower their risks of cardiovascular events. This study is an important reaffirmation of the role of dietary choices in beneficially impacting key markers of health and longevity.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment and reversal of age-related dysfunction, disorders and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavours and to sign up for your free subscription to the Longevity Magazine™ e-Journal.

Filed under: Longevity News & Review

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