March 11-17, 2011

By Dr Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, and Dr Ronald Klatz, M.D., D.O., A4M President, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Green Tea Compounds Counteract Aging  
The Free Radical Theory of Aging, initially introduced by Dr R Gerschman and subsequently developed by Dr Denham Harman, submits that volatile and destructive intracellular biochemical interactions could be attributed to the presence of molecules in which the electrical charge is not balanced. Such “free radicals” most notably cause oxidation, a process which can be deleterious to cells of the body. A number of studies have suggested an interventive role for antioxidant compounds in counteracting free radical damage. Subramanian Kaviarasan, from the University Annamalai in India, and colleagues found that polyphenols – a type of antioxidant – present in green tea, possess a high capacity to scavenge hydroxyl radicals, noting that it “possesses protective action against peroxide-induced mitochondrial damage, radiation induced DNA damage and [has] high redox potential.”

Dr Klatz observes: In reporting that polyphenols present in green tea exert a potent antioxidant effect that helps to counteract free radical damage to cells, these scientists elucidate a novel nutritional approach that potentially may retard a leading mechanism of aging.

Activity Promotes Cardiometabolic Fitness 
While sedentary time has become part of the Western lifestyle, sitting for prolonged periods of time worsens key cardiometabolic risk factors. Genevieve Healy, from the University of Queensland, and colleagues analyzed data collected on 4,757 American men and women, mean age 46.5 years, enrolled in a three-year period in the US National Health and Nutrition Examination Survey. Study subjects wore an accelerometer on their hip to record the amount of time spent standing or sitting still or being active, with sedentary time defined as any time period when the accelerometer read fewer than 100 counts per minute. On average, the participants wore the accelerometer for 14.6 hours a day, of which 8.44 hours was sedentary time that was broken up an average of 92.5 times a day, with a mean break duration of about four minutes. After adjusting for confounding factors, the team found that increases in sedentary time were associated with worsening trends in several cardiometabolic markers, most notably – waist circumference, HDL cholesterol, C-reactive protein, fasting triglycerides, insulin, and measures of insulin resistance. In contrast, periodically standing up and moving about for as little as a minute was associated with beneficial changes in waist circumference and C-reactive protein. Explaining that: “These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers,” the researchers conclude that: “The findings suggest that clinical communications and preventive health messages on reducing and breaking up sedentary time may be beneficial for cardiovascular disease risk.”

Remarks Dr Goldman: Revealing that a sedentary lifestyle is associated with a worsening of several cardiometabolic risk factors, including waist circumference, HDL cholesterol, and C-reactive protein, these researchers reaffirm the multiple physiological benefits of physical activity.

Tomato Compound Combats Vascular Diseases 
Tomatoes are rich in 9-oxo-octadecadienoic acid, and Teruo Kawada, from Kyoto University, and colleagues explored the role of these compounds in affecting dyslipidemia, a condition which is caused by an abnormal amount of lipids, such as cholesterol or fat, in the bloodstream. The team analyzed 9-oxo-octadecadienoic acid, and found it enhanced fatty acid oxidation and contributed to the regulation of hepatic lipid metabolism, via the peroxisome proliferator-activated receptor alpha pathway.  As a result, the researchers posit that 9-oxo-octadecadienoic acid exerts anti-dyslipidemia affects and may aid in the prevention of vascular diseases. 

Comments D. Klatz: Tomato is one of the most common crops worldwide, and this research team reveals the widely accessible fruit contains many beneficial compounds that improve abnormalities of lipid metabolism.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription to Longevity Magazine™ e-Journal.

Filed under: Longevity News & Review

One Response to “March 11-17, 2011”

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