May 27-June 2, 2011

By Dr Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, and Dr Ronald Klatz, M.D., D.O., A4M President, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Cancer-Prevention Lowers Mortality
Following recommendations for cancer prevention has been found to significantly reduce the risk of dying from all causes. Researchers led by Marji McCullough at the American Cancer Society used diet and lifestyle questionnaires filled out by 111,966 non-smoking men and women in the Cancer Prevention Study (CPS)-II Nutrition Cohort to determine whether people that followed recommendations for cancer prevention had a lower risk of death from cancer, cardiovascular disease and all-causes. Results showed that after 14 years participants with high compliance scores (7-8) had a 42-percent lower risk of death compared to those with low compliance scores (0-2). The risk of dying from cardiovascular disease was 48 percent lower in men and 58 percent lower in women with high compliance scores. Whilst the risk of dying from cancer was 30-percent lower in men and 24-percent lower in women.  Similar, although not always statistically significant, reductions were observed for never and former smokers.

Dr Klatz observes: By closely adhering to cancer prevention guidelines, one may reap the life-extending benefits of an anti-aging lifestyle, most notably in markedly reducing the risk of dying from all-causes, as well as specifically from cancer and/or cardiovascular disease.

Resistance Training Offsets Muscle Loss
University of Michigan scientists reveal that not only can we fight the battle of strength and muscle loss as we age, we can even build muscle and strength well into seniorhood.  “Resistance exercise is a great way to increase lean muscle tissue and strength capacity so that people can function more readily in daily life,” says Mark Peterson, from the University of Michigan Physical Activity and Exercise Intervention Research Laboratory, explaining that: “Our analyses of current research show that the most important factor in somebody’s function is their strength capacity. No matter what age an individual is, they can experience significant strength improvement with progressive resistance exercise even into the eighth and ninth decades of life.”

Remarks Dr Goldman: Older adults need not accept loss of muscle strength as they age: by implementing a regular program of resistance training, we can maintain muscle fitness well into our later years.

Citrus Compounds Reduce Inflammation
An extensive body of epidemiological studies has linked increased dietary intake of antioxidants from fruits, vegetables, wine, chocolate, coffee, tea and other foods to reduced risks of a range of diseases including cancer, cardiovascular disease and diabetes. Increased intakes of compounds called flavonoids from citrus may be associated with lower levels of markers of inflammation, reports Rikard Landberg, from the Swedish University of Agricultural Sciences, and colleagues. Women with the highest intakes of total flavonoids, which includes various subclasses such as flavones, flavonols, flavanones, flavan-3-ols, anthocyanidins, and polymeric flavonoids, had an 8-percent lower level of the pro-inflammatory compound interleukin-18 (IL-18), compared with women with the lowest intake. In addition, women with the highest average intakes of flavonol had 4-percent lower levels of soluble vascular adhesion molecule-1 (sVCAM-1), compared with women with the lowest average intakes.

Comments Dr Klatz: Citrus flavonoids may lower one’s markers of inflammation, suggesting a potentially vital functional health role for these widely accessible antioxidant compounds.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription to Longevity Magazine™ e-Journal.

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