August 05-11, 2011

By Dr Robert Goldman

Longevity News and Review provides readers with the latest    information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, and Dr Ronald Klatz, M.D., D.O., A4M President, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Anti-Aging Lifestyle Reduces Sudden-Death Risk
Sudden cardiac death (SCD) accounts for more than 50 percent of coronary heart disease mortality, with SCD often being the first manifestation of CHD in women. In that previous studies have suggested that several modifiable lifestyle factors are associated with SCD, Stephanie E. Chiuve, from Harvard School of Public Health, and colleagues examined the individual and cumulative impact of these factors on SCD risk in participants in the Nurses’ Health Study.   Their analysis included 81,722 women, ages 30 to 55 at enrollment, who completed lifestyle questionnaires every two to four years, beginning in 1984. The team defined a “low-risk lifestyle” as no smoking, body mass index (BMI) less than 25, at least 30 minutes of exercise daily, and top 40 percent of the alternate Mediterranean diet score – emphasizing the consumption of vegetables, fruits, nuts, legumes, whole grains and fish, and moderate alcohol intake. During the 26 years of follow-up, 321 SCD events occurred, involving women whose median age was 72 at the time of the incident. Women who adhered to the “low-risk lifestyle” had as much as a 90-percent reduction in the risk of SCD, compared with those with a high-risk profile. Compared with women with none of the low-risk attributes, the risk of SCD declined linearly as the number of these attributes increased, ranging from a 46-percent reduction for a woman who had one to 92 percent for those who had all four. Observing that about 80 percent of attributable risk for SCD was associated with the four lifestyle factors included in the analysis, the researchers conclude that: “Adherence to a low-risk lifestyle is associated with a low risk of [sudden cardiac death].”

Dr Klatz observes: Reporting that daily physical activity, a low-fat whole-grain diet, low BMI and other healthy behaviours significantly reduce a woman’s risk of sudden cardiac death, these researchers reaffirm the life-extending benefits of the anti-aging lifestyle.

Protein-Rich Diet Curbs Appetite
Previously, research has shown that higher-protein diets, containing 18 to 35 percent of daily calorie intake from dietary protein, are associated with reductions in hunger and increased fullness throughout the day and into the evening hours. Heather Leidy, from the University of Missouri, and colleagues completed  study in which two groups ate either 25 or 14 percent of calories from protein, while the total calories and percent of calories from fat stayed the same between the higher-protein and normal-protein diet patterns.   Concurrently, the team also conducted an eating frequency substudy in which the 27 participants on both normal- and higher-protein diets consumed either three meals or six meals per day. The researchers found that eating frequency had no effect on appetite and satiety on the normal-protein diet. However, subjects on the higher-protein diet who ate three meals per day experienced greater evening and late-night fullness than those who ate six meals per day. The team concludes that: “Collectively, these data support the consumption of [higher protein] intake, but not greater eating frequency, for improved appetite control and satiety in overweight/obese men during energy restriction-induced weight loss.”

Remarks Dr Goldman: Higher-protein meals improve perceived appetite and satiety, among overweight and obese men during weight loss. This finding underscores the need to maintain quality food choices, especially when seeking to shed pounds.

Vitamin D for Longevity
Many older women, particularly those in institutionalised care, are vitamin D deficient and at increased risk of falls and fractures.  Goran Bjelakovic, from the University of Nis in Serbia, and colleagues completed a meta-analysis of 50 randomized trials that collectively involved 94,148 participants, with a mean age of 74 years. The team’s analysis suggested that vitamin D3 (cholecalciferol) supplementation reduces mortality by about 6 percent, equating to saving one life for every 200 people given vitamin D3 for two years. The researchers conclude that: “Vitamin D3 seems to decrease mortality in predominantly elderly women who are mainly in institutions and dependent care.”

Comments Dr Klatz: Finding that Vitamin D supplementation extends longevity among older women, this team reinforces the amassing literature suggesting both life-enhancing and life-extending benefits to this vitamin.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription to Longevity Magazine™ e-Journal.

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