December 2-8, 2011

By Dr Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, and Dr Ronald Klatz, M.D., D.O., A4M President, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Is Happy Disposition Key to Long Life?
A British study finds that older adults who report feeling happy and content live longer than others. Andrew Steptoe, from the University College London, and colleagues monitored “positive affect” (states such as happiness, peacefulness and excitedness), and “negative affect” (anxiety and hostility, for example), among 3,850 people ages 52 to 79 years who were asked to describe their feelings – happy, excited, content, worried, anxious or fearful – four times during one 24-hour period. Then, the team tracked the participants for the next five years, and found that over 7 percent of those who died were in the lowest third of those with positive affect, compared to 6 percent in the third with the highest level of positive affect. Even after ruling out confounding factors, the researchers found that those who said they were the most happy were 35 percent less likely to die than those who described themselves as the least happy. The study authors conclude that: “The results endorse the value of assessing experienced affect, and the importance of evaluating interventions that promote happiness in older populations.”

Dr Klatz observes: This supports prior evidence that lends credence to the life-extending benefits of a positive attitude.

Co-Q10 Helps Reduce Exercise-Related Muscle Damage    
Co-enzyme Q10 – also known as ubiquinone – is a powerful antioxidant found in every cell of the body, where it has important functions within the mitochondria – the “powerhouses” of cells. Javier Diaz-Castro, from the University of Granada in Spain, and colleagues studied elite runners participating in a 50-kilometer run across Europe’s highest road in the Sierra Nevada. Twenty athletes participated in the study who were divided into two groups: one group received one 30mg capsule of Q10 two days before the run, three 30mg capsules the day before the run and one capsule one hour prior to the run. The other group received placebo at the same time. Whereas the placebo group displayed a 100-percent increase in oxidative stress markers, only 37.5 percent of the Q10-supplemented runners experienced the same stresses. Suggesting that Q10 countered the overexpression of certain pro-inflammatory compounds after exercise, the researchers conclude that: “Co Q10 supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signalling, reducing the subsequent muscle damage.”

Remarks Dr Goldman: Adding to the body of evidence that supports the role of Co-enzyme Q10 supplementation in counteracting oxidative stress, these researchers reveal a potentially important therapeutic approach to reduce the effects of strenuous exercise and related subsequent muscle damage.

Resveratrol May Benefit Oral Health
Resveratrol, a bioactive compound found in grapes and red wine, has been most extensively studied to date for its potential to increase lifespan in laboratory models of aging, as well as for its anti-inflammatory benefits that may extend cardiovascular, cancer and diabetes benefits in humans. R.W.K. Wong, from The University of Hong Kong, and colleagues studied the effects of resveratrol on two strains of bacteria involved in periodontal disease. After incubating the bacteria with resveratrol for one hour, significant decreases in the bacteria counts were observed; no viable bacterial cells were observed after 24 hours of incubation with resveratrol. The researchers conclude that: “The results suggest that resveratrol possesses significant antimicrobial properties on periodontal pathogens in vitro.”

Comments Dr Klatz: This team’s findings support emerging data that suggests the compound exerts vital anti-pathogenic activity.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavours and to sign-up for your free subscription to Longevity Magazine™ e-Journal.

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