Mar. 30-Apr. 5, 2012

By Dr Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, and Dr Ronald Klatz, M.D., D.O., A4M President, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Anti-Aging Tenets for Lifetime of Health  
While most men and women in their 40s acknowledge that maintaining a low cardiovascular disease risk profile may associate with better health outcomes in older age, few middle-aged adults actually attain such a profile. Kiang Liu, from Northwestern University Feinberg School of Medicine (Illinois), and colleagues analysed data collected over a 20-year period, from the Coronary Artery Risk Development in Young Adults Study, which began in 1985 with 3,154 subjects, ages 18 to 30 years at the time. In the first year of the study, when the average age of participants was 24 years, nearly 44 percent had low cardiovascular disease risk profile. Twenty years later overall, only 24.5 percent remained in that profile category: the researchers observed that these subjects maintained five healthy lifestyle factors from young adulthood, including – lean body mass index (BMI), modest alcohol intake (if any), no smoking, healthy diet and routine physical activity. The study authors urge that: “Maintaining a healthy lifestyle throughout young adulthood is strongly associated with a low cardiovascular disease risk profile in middle age.”

Dr Klatz observes: This large-scale study reports that by following healthy lifestyle habits in one’s 20s a person may markedly lower his/her risk of cardiovascular disease in their 40s. These data further support the notion that the adoption of an anti-aging lifestyle may confer life-saving benefits later in life.

Exercise Invigorates    
Many of us are well-intended to commit to a routine of regular exercise; however the reality often falls short of the intention. Penn State University researchers asked 190 university students to keep daily diaries of their lived experiences, including free-time physical activity and sleep quantity and quality, as well as their mental states, including perceived stress and feeling states. Participants were instructed to record only those episodes of physical activity that occurred for at least 15 minutes and to note whether the physical activity was mild, moderate or vigorous. Participants returned their diaries to the researchers at the end of each day for a total of eight days. The team then separated the participants’ feeling states into four categories: pleasant-activated feelings exemplified by excitement and enthusiasm, pleasant-deactivated feelings exemplified by satisfaction and relaxation, unpleasant-activated feelings exemplified by anxiety and anger and unpleasant-deactivated feelings exemplified by depression and sadness. The researchers found that people who were more physically active had more pleasant-activated feelings, compared to people who were less active. Additionally, the team observed that people had more pleasant-activated feelings on days when they were more physically active.

Remarks Dr. Goldman: Reporting that people who are more physically active report greater levels of excitement and enthusiasm, these researchers add to the ever-growing body of scientific evidence demonstrating the benefits to both physical – and mental – health.

Orange Compound May Reduce Stroke Risk    
A number of studies have suggested that Vitamin C exerts a protective effect in warding off stroke. Aedín Cassidy, from the University of East Anglia, and colleagues completed an analysis of data compiled in the Nurses’ Health Study, finding that the vitamin did not correlate with either total or ischemic stroke risk. Instead, the researchers found that flavanone, an antioxidant compound found in oranges, grapefruit, and other citrus fruits, seem to exert a modest stroke risk reduction. In their analysis of the data involving 69,622 women, who were followed for 14 years, the team found that women with the highest levels of flavanone were 19 percent less likely to have an ischemic stroke, as compared to those with the least flavanone intake. Positing that flavanone may exert a protective effect involving the nitric oxide pathway, the study authors conclude that: “Citrus fruit consumption may be associated with a reduction in stroke risk, and experimental data support these epidemiological associations that the flavanone content of citrus fruits may potentially be cardioprotective.”

Comments Dr. Klatz: In revealing a biological pathway for the antioxidant compound flavonone, this team identifies a potentially potent functional health role for citrus fruits in intervening in stroke risk among women.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavours and to sign-up for your free subscription to Longevity Magazine™ e-Journal.

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