Jul. 27-Aug. 2, 2012

By Dr Robert Goldman & Dr Ronald Klatz

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent and treat aging related disease and to promote research into methods to retard and optimise the human aging process. Dr Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, and Dr Ronald Klatz, M.D., D.O., A4M President, physician co-founders of the anti-aging medical movement, distil these headlines and provide their commentary.

Simple Eye Test May Assess Stroke Risk
Carotid artery stenosis (CAS) is a condition that clogs or blocks the arteries that feed the front part of the brain, and is considered a risk factor for stroke. Pascal B. Knecht, from the University Hospital Zurich (Switzerland), and colleagues report that an ophthalmological test called ocular pulse amplitude (OPA) can reliably detect CAS. The researchers used a device called the dynamic contour tonometer to check the OPA of 67 patients who were assumed to have CAS. The OPA score is calculated by finding the difference between the two pressure levels that occur inside the eye during the two phases of the heartbeat ? the systolic and diastolic. The tonometer measures the two pressure levels, then instantly computes the patient’s OPA score. When blood flow to the eye is blocked by CAS, there is not much difference between the two pressure levels, so the OPA score is low. The study confirmed that patients with the lowest OPA scores also had the most seriously blocked arteries. The researchers used ultrasound exams to corroborate that each study participant had CAS and to detail the severity of his or her blockage. The study authors conclude that: “The results of the present study provide proof of principle that the [ocular pulse amplitude] is reduced in patients with [carotid artery stenosis] and may be used as a noninvasive, inexpensive, readily available, and unconfounded screening parameter to detect [carotid artery stenosis] and possibly to reduce the incidence of stroke.”

Dr Klatz observes: Reporting that the ocular pulse amplitude (OPA) test may offer an effective way to identify patients who are at high risk for stroke, these researchers suggest an innovation in low cost, easy access diagnostics to assess stroke risk.

Grape Compound Enhances Exercise Performance
Resveratrol is an antioxidant compound found abundantly in red grapes and red wine, for which a number of cardiovascular and cognitive health benefits have been suggested. Jason R. B. Dyck, from the University of Alberta (Canada), and colleagues have observed that high doses of the resveratrol improve physical performance, heart function and muscle strength in lab models. Finding that endurance capacity is enhanced in rats whose diet includes resveratrol during a 12-week endurance-training programme, and that the increased endurance was associated with increases in skeletal muscle force, cardiac function, and oxidative metabolism, the study authors report that: “Our results establish that resveratrol is an effective ergogenic aid that enhances exercise performance over exercise alone.”

Remarks Dr. Goldman: Finding that resveratrol improves strength and endurance, in lab models, it will be intriguing to see if further studies – in humans – reveal a similar outcome.

Dental Plaque May Indicate Cancer Risk
Poor oral hygiene may be associated with increased risk of cancer and premature death, reports a Swedish study. In 1985, Birgitta Soder, from the Karolinska Institutet (Sweden), and colleagues initiated a longitudinal study of 1,390 randomly selected, healthy Swedish adults, ages 30 to 40 years, who had no signs of periodontitis at baseline. The participants were followed with periodic checkups including smoking habits and oral health through 2009. Dental plaque measures were taken at the study start and in 1996, 1998, 2000, 2001, and 2009. Over the 24-year study period, 58 patients died, including 35 deaths due to malignancies. Individuals still alive at the end of follow-up had a significantly lower dental plaque index than those who died, with statistically significant differences regarding the amount of dental plaque, gingival inflammation, and dental calculus, indicating a significantly poorer dental status in the subjects who died when compared with survivors. The study authors conclude that: “poor oral hygiene, as reflected in the amount of dental plaque, was associated with increased cancer mortality.”

Comments Dr. Klatz: An indicator of poor oral hygiene and a potential source of dental infections, the amount of dental plaque may predict death from cancer. These data suggest a modifiable risk factor for cancer that may become an important public health message.

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavours and to sign-up for your free subscription to Longevity Magazine™ e-Journal.

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