October 12-18, 2012

By Dr Robert Goldman & Dr Ronald Klatz

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Study Reveals Secrets of ‘Cognitive SuperAgers’ Brains
Emily Rogalski, assistant research professor at the Cognitive Neurology and Alzheimer’s Disease Center at Northwestern University Feinberg School of Medicine, and colleagues set about studying 3D-MRI scans of 12 so-called SuperAgers – people aged 80 and over with episodic memory performance at least as good as those aged 50-65. Results showed that the cerebral cortex of the SuperAgers was significantly thicker than that of their healthy age-matched peers, and that it closely resembled the cortex size of participants ages 50 to 65. Furthermore, a specific region of the cortex was significantly thicker in the SuperAgers than in both elderly and middle-aged controls. “These findings are remarkable given the fact that grey matter or brain cell loss is a common part of normal aging,” said Rogalski. The authors concluded: “Our findings identify cognitive and neuroanatomical features of a cohort that appears to resist average age-related changes of memory capacity and cortical volume. A better understanding of the underlying factors promoting this potential trajectory of unusually successful aging may provide insight for preventing age-related cognitive impairments or the more severe changes associated with Alzheimer’s disease.”

Dr. Klatz observes: “There has been a lot of research investigating what goes wrong in the brains of older people with dementia, but almost no research doing the same for elderly people whose memory is still as sharp as it was decades earlier. Now, researchers have used 3-D MRI scans to see what exactly is going on in the brains of elderly people whose memories are as sharp as those several decades younger.”

30 Minutes of Exercise Effective for Weight Loss
Mads Rosenkilde and colleagues at the University of Copenhagen (Denmark) conducted a randomized controlled study on 60 sedentary and moderately overweight young men to examine the effects of increasing doses of aerobic exercise on weight loss. Half of the men were assigned to exercise for an hour a day, while the second half only had to exercise for 30 minutes. Results showed that, on average, the men who exercised 30 minutes a day lost 3.6 kg in 3 months, while those who exercised for a whole hour only lost 2.7 kg. The reduction in body mass was about 4 kg for both groups. Furthermore, participants who exercised for just 30 minutes burned more calories than expected. “Exercising for a whole hour instead of a half does not provide any additional loss in either body weight or fat,” concluded PhD student Rosenkilde.

Remarks Dr. Goldman: “When it comes to losing weight, ‘more is better’ may not hold true. Denmark team reports that exercising for just 30 minutes is as effective for weight loss as a whole hour.”

Olive Oil May Reduce Cardiovascular Risk by Boosting Endothelial Function
Research suggests that supplementing the diet with olive oil may help to reduce cardiovascular risk by improving the function of the endothelial cells that line the blood vessels. Researchers from the Mayo Clinic and College of Medicine and from the Department of Pharmaceutical Sciences at the University of Florence (Italy), investigated the effects of supplementing the diet with 30 ml/day of olive oil (providing 340 mg/kg polyphenols) on endothelial function. Eighty-two people with atherosclerosis participated in the double-blind, randomized, 4-month long trial, and 52 participants completed the study. Results showed that olive oil consumption “significantly improved endothelial function”. A “significant reduction in inflammatory parameters” was also observed. The researchers concluded: “Supplementation with olive oil seems a reasonably easy and relatively cheap dietary measure to improve the endothelial function and perhaps favorably alter the progression of atherosclerotic disease, particularly in patients with already markedly impaired endothelial function.”

Comments Dr. Klatz: “Regular consumption of olive oil may help to reduce cardiovascular risk by improving the function of cells that line the blood vessels.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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