Oct. 26 – Nov. 1, 2012

By Dr Robert Goldman & Dr Ronald Klatz

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Black Pepper Contains Anti-Cancer Compound
Several previous studies suggest that piperine, an alkaloid compound found abundantly in black pepper, has diverse physiological actions including the ability to kill cancer cells. Carolyn D. Doucette, from Dalhousie University (Canada), and colleagues explored the effect of piperine on angiogenesis – a key process for tumor growth and progression, in a lab animal model. The team found that piperine inhibited the conversion of certain regulators of endothelial cell function and angiogenesis, as well as inhibited the pathway that is implicated in the proliferation and transition of tumors from a dormant state to a malignant one. The study authors conclude that: “these data support the further investigation of piperine as an angiogenesis inhibitor for use in cancer treatment.”

Dr. Klatz observes: “Angiogenesis is a physiological process enabling the growth of new blood vessels from pre-existing ones. A vital mechanism for wound healing, angiogenesis is also a key process involved in tumor growth and progression. This team reveals that piperine, a compound found abundantly in black pepper, inhibits cellular mechanisms that are necessary in angiogenesis.”

Exercise Helps to Protect Against Anxiety & Stress
J. Carson Smith, from the University of Maryland (Maryland, USA), enrolled 37 healthy and normally physically active young adults to complete two exercise regimens on separate days: the first, 30-minutes of seated rest; and the second, 30-minutes of moderate intensity cycle ergometer exercise (Rated Perceived Exertion of 13; ‘somewhat hard’). The researcher assessed the subjects’ anxiety state before the period of activity (or rest), shortly afterward (15 minutes after) and finally after exposing them to a variety of highly arousing pleasant and unpleasant photographs, as well as neutral images. At each point, study participants answered 20 questions from the State-Trait Anxiety inventory, which is designed to assess different symptoms of anxiety. All participants were put through both the exercise and the rest states (on different days) and tested for anxiety levels pre-exercise, post-exercise, and post-picture viewing. The researcher found that exercise and quiet rest were equally effective at reducing anxiety levels initially. However, once the subjects were emotionally stimulated (by being shown the photographs), the anxiety levels of those who had simply rested went back up to their initial levels, whereas those who had exercised maintained their reduced anxiety levels. Reporting that: “These findings suggest the anxiolytic effects of acute exercise may be resistant to the potentially detrimental effects on mood after exposure to arousing emotional stimuli,” the study author comments that: “exercise helps to buffer the effects of emotional exposure. If you exercise, you’ll not only reduce your anxiety, but you’ll be better able to maintain that reduced anxiety when confronted with emotional events.”

Remarks Dr. Goldman: “In that moderate exercise may help people cope with anxiety and stress for an extended period of time post-workout, this data suggests that physical activity may help people to better endure life’s daily emotional challenges.”

Vitamin D Deficiency Raises Risk of Heart Disease
Peter Brondum-Jacobsen, from the University of Copenhagen (Denmark), and colleagues utilized data collected from 10,000 Danes enrolled in the Copenhagen City Heart Study, which measured levels of vitamin D in blood, comparing the 5% lowest levels of vitamin D (less than 15 nanomol per liter serum) with the 50% highest levels (more than 50 nanomol per liter serum)., and then followed nationwide Danish registries for hospital admissions. The team observed that low levels of vitamin D compared to optimal levels are linked to 40% higher risk of ischemic heart disease, 64% higher risk of heart attack, 57% higher risk of early death, and to no less than 81% higher risk of death from heart disease. The study authors summarize that: “We observed increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing plasma 25-hydroxyvitamin D levels.”

Comments Dr. Klatz: “Most often associated with poor bone health, vitamin D deficiency may also raise a person’s risk of ischemic heart disease – which may manifest as heart attack, coronary arteriosclerosis, or angina. Other studies suggest that vitamin D deficiency may increase blood pressure and consequently, the risk of heart attack. This large-scale Danish study reports that low levels of vitamin D are associated with a markedly higher risk of heart attack as well as early death.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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