Nov. 30-Dec. 6, 2012

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Lung Health Linked to Brain Health
Charles Emery, from Ohio State University (Ohio, USA), and colleagues assessed data collected on 832 subjects, ages 50 to 85 years at the study’s start, who were assessed in up to seven waves of testing across 19 years as part of the longitudinal Swedish Adoption/Twin Study of Aging. The team conducted statistical modeling designed to show the patterns of change over time. Their analysis revealed that reduced pulmonary function can lead to cognitive losses – specifically, difficulties with problem-solving and processing speed. They did not find problems with cognition to affect lung health. The study authors conclude that: “these data indicate a directional relationship from decreased pulmonary function to decreased cognitive function, a finding that underscores the importance of maintaining pulmonary function to ensure cognitive performance.”

Dr. Klatz observes: “Whereas previous studies suggest that pulmonary function predicts long-term performance (up to 10 years) on measures of cognitive function, new data suggests that problem-solving and processing speed are impacted by reduced pulmonary function. By keeping the lungs healthy, people may increase their retention of cognitive functions as they age.”

Soccer Scores on Blood Pressure
Peter Krustrup, from the University of Exeter (United Kingdom), and colleagues recruited 33 men, ages 33 to 54 years, with mild to moderate hypertension, and randomly divided them in two groups: one took part in two hour-long soccer training sessions a week, while the other received usual care by a general practitioner including advice about the importance of physical activity and a healthy diet, together with control blood pressure measurements (control group). The effects on exercise capacity, maximal oxygen uptake, body fat and blood pressure, were monitored after three months and at the end of the six-month trial. For the soccer-playing group, average mean blood pressure was reduced by 10 mmHg, while the reduction was only 5 mmHg in the control group receiving the medical advice. For the football group, maximal oxygen uptake and maximal exercise capacity was improved by10%, resting heart rate decreased by 8 beats per minute and body fat mass dropped by an average of 2 kilograms. No significant changes to these health measures were observed in the control group. As well, the men who took part in soccer training were also found to be less physically strained during moderate intensity exercise. Writing that: ‘Six months of soccer training improved aerobic fitness, reduced blood pressure and resulted in an array of other favourable effects on cardiovascular risk profile for untrained middle-aged hypertensive men,” the study authors suggest that: “Soccer training may, therefore, be a better non-pharmacological treatment for hypertensive men than traditional physician-guided advice.”

Remarks Dr. Goldman: “A major risk factor for stroke, high blood pressure (hypertension) affects approximately 970 million people worldwide. Soccer (known as football outside the US) helps men with high blood pressure (hypertension) to improve their fitness, normalize their blood pressure. and reduce their risk of stroke.”

Curry Compound Curtails Cancer
Curcumin, a spice compound extracted from the rootstalks of the turmeric plant and gives curry its yellow color and pungent flavor, has been used for centuries in folk medicine and is becoming recognized for its ability to curb the inflammatory response. In previous work, Beatrice Bachmeier, from Ludwig-Maximillians University Munchen (Germany), and colleagues established that curcumin reduces statistically significantly the formation of lung metastases in an animal model of advanced breast cancer. In the present study, the researchers aimed to investigate the efficacy of curcumin in the prevention of prostate cancer metastases, and to determine the compound’s mechanism of action. The researchers first examined the molecular processes that are abnormally regulated in prostate carcinoma cells, finding that tumor cells produce pro-inflammatory immunomodulators including the cytokines CXCL1 and CXCL2. The researchers demonstrated hat curcumin specifically decreases the expression of these two proteins, and in a mouse model, this effect correlated with a decline in the incidence of metastases. Observing that: “Chronic inflammation can induce a metastasis prone phenotype in prostate cancer cells by maintaining a positive pro-inflammatory and pro-metastatic feed-back loop between [inflammatory markers implicated in cancer],” the study authors conclude that: “Curcumin disrupts this feed-back loop by the inhibition of NF?B signalling leading to reduced metastasis formation in vivo.”

Comments Dr. Klatz: “One of the most prevalent malignancies in the Western world, prostate cancer is often only diagnosed only after metastatic tumors have formed in other organs; in 3% of cases, these metastases are lethal. Curcumin, the spice compound that gives curry its yellow color and pungent flavor, may inhibit formation of metastases, in a lab model of prostate cancer.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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