December 21-27, 2012

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Anti-Aging Lifestyle Promotes Independent Living
Severine Sabia, from University College London (United Kingdom), and colleagues studied a group of 5100 men and women, ages 42 to 63 years, who were enrolled in the Whitehall II study. The team defined a set of four healthy behaviors: namely, never smoking, moderate alcohol consumption, physical activity (2.5 h/wk or more of moderate physical activity or1 h/wk or more of vigorous physical activity), and eating fruits and vegetables daily. We defined successful aging, measured over a median 16.3-year follow-up, as good cognitive, physical, respiratory and cardiovascular functioning, in addition to the absence of disability, mental health problems and chronic disease (coronary artery disease, stroke, cancer and diabetes). The researchers revealed that people in the successfully aging group were younger than the normally aging group (mean age 49.7 versus 51.3 yr), and 81% were married compared with 78% in the second group and 71% in the deceased group. Successful agers were more likely to have higher education than the normally aging group (32% v. 24%) and 18% in the deceased group. In the study population, Observing that: “participants engaging in all 4 healthy behaviours had 3.3 times greater odds of successful aging,” the study authors conclude that: “Although individual healthy behaviours are moderately associated with successful aging, their combined impact is substantial.”

Dr. Klatz observes: “For most people, the ability to retain mobility, cognitive skills, respiratory function, mental health and enjoy a life free of chronic diseases, is a key facet to aging well. The precepts of the anti-aging lifestyle – including healthy diet, exercise, alcohol in moderation, and not smoking – help people to maintain physical and cognitive capacities as they age.”

Lifting Weights Wards Against Metabolic Syndrome
Peter M. Magyari, from University of North Florida (Florida, USA), and colleagues analyzed data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES), an ongoing, nationally representative study of health risk factors. In the survey, respondents were simply asked whether they lifted weights; the responses were analyzed for association with the presence of metabolic syndrome. Of 5,618 U.S. adults who had fasting blood samples for analysis, 8.8% answered yes to the question about lifting weights. Lifting weights was about twice as common in men than women: 11.2 versus 6.3%. It was also more common among younger people – lifting weights became less frequent for people aged 50 years and older. The investigators observed that Metabolic Syndrome was far less prevalent among people who reported lifting weights: 24.6%, compared to 37.3% n those who did not lift weights. The study authors urge for the: “[strong encouragement of] the activity of [lifting weights] among adults of all ages to promote metabolic health.”

Remarks Dr. Goldman: “Metabolic Syndrome is a cluster of risk factors including central obesity, hypertension, and adverse glucose and insulin metabolism that is linked to increased rates risk of cardiovascular disease and diabetes. These researchers report that people who lift weights are less likely to have metabolic syndrome.”

Food AGEs You
Produced with high-temperature cooking such as grilling, advanced glycation end products (AGEs) may worsen heart issues often seen as complications of diabetes. AGEs characterize vascular plaques, a characteristic of cardiovascular disease. Karen Chapman-Novakofski and colleagues compared the 10-day food intake of 65 study participants in two ethnic groups: Mexicans (who have higher rates of diabetes and a greater risk of complications from the disease) and non-Hispanic whites. The team found that subjects with higher rates of cardiovascular complications ate more of AGEs: for each unit increase in AGEs intake, a study participant was 3.7 times more likely to have moderate to high risk for cardiovascular disease. Urging that diabetics should eat less saturated fat and more fruits, vegetables, and fiber, the researchers submit that their data shows that the method of food preparation may as important a factor.

Comments Dr. Klatz: “While nutrition experts have advised people with diabetes to bake, broil, or grill their food instead of frying, University of Illinois (Illinois, USA) researchers report that any cooking methods that involve high, intense, dry heat capable of creating a crust produce advanced glycation end products (AGEs).”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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