Dec. 28, 2012-Jan. 3, 2013.

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Health Status Linked to Happiness
Erik Angner, from George Mason University (Virginia, USA), and colleagues developed a direct measure of the degree to which disease disrupts daily functioning. Their “freedom-from-debility score” is based on four health survey questions explicitly designed to represent limitations in physical activities and in usual role activities because of health problems. The researchers found that when controlling for demographic and socioeconomic factors in addition to objective and subjective health status, a one-point increase in the freedom-from-debility score (on a scale from 0 to 100) was associated with a three-percent reduction in the odds of reported unhappiness. The study authors submit that: “health status is one of the most influential predictors of happiness, that the association between health status and happiness depends greatly on the manner in which health status is measured, and that the degree to which disease disrupts daily functioning is inversely associated with happiness.”

Dr. Klatz observes: “Previously, studies link self-perceived happiness to the absence or presence (and the degree thereof) of having a medical condition. This team finds that the degree to which a disease disrupts daily functioning associates with reduced happiness.”

Sports Promote Smarts
Anil Nigam, from the University of Montreal (Canada), and colleagues assessed the effects of high-intensity interval training, on a group of six middle-aged men and women. All subjects had a body mass index (BMI) between 28 and 31, in addition to one or more cardiovascular risk factors. The participants followed a four-month program of twice-weekly interval training on stationary bicycles and twice-weekly resistance training. At the end of the study period, trunk fat mass decreased while VO2max and insulin sensitivity rose. Notably, oxygenation of blood in the brain increase significantly, and performance on standardized cognitive tests improved. The study authors report that: “the benefits of physical activity appear to be directly linked to the notion of training volume and intensity.”

Remarks Dr. Goldman: “Regular exercise is shown by a number of studies to partially reverse the effects of the aging process on physiological functions and preserve functional reserve. Four months of a high-intensity interval training program dramatically increased cognitive performance, among middle-aged people with increased cardiovascular risk.”

Omega-3 Improves Memory
Rajesh Narendarn. From University of Pittsburgh (Pennsylvania, USA), and colleagues studied a group of young adults, 18 to 25 years, who were supplemented with omega-3 fatty acids (2 g/day containing docosahexaenonic acid, DHA 750 mg/d and eicosapentaenoic acid, EPA 930 mg/d), for a six month period. Prior to taking the supplement, the subjects underwent brain imaging and blood draws; they also performed a working memory test. At the end of the study period, all participants underwent the same assessment procedures. The investigators found that working memory improved dramatically, prompting them to comment that: “Before seeing this data, I would have said it was impossible to move young healthy individuals above their cognitive best … We found that members of this population can enhance their working memory performance even further.”

Comments Dr. Klatz: “Previously, a number of studies suggest that dietary or supplemental sources of omega-3 fatty acids help to improve cognitive function, among aging adults. These researchers report that dietary supplementation of omega-3 fatty acids boosts working memory, among healthy young adults.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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