January 11-17, 2013

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Add 14 Years to Your Life by Optimizing Cardiovascular Profile
John T. Wilkins, from Northwestern University (Illinois, USA), and colleagues selected data from five different cohorts included in the Cardiovascular Lifetime Risk Pooling Project and analyzed the participants’ risk of all forms of fatal and nonfatal cardiovascular disease from ages 45, 55 and 65 through 95 years of age. The team found that subjects with optimal risk factor profiles lived up to 14 years longer free of total cardiovascular disease, as compared to individuals with at least two risk factors. Lifetime risks for cardiovascular disease were strongly associated with risk factor burden in middle age. The study authors submit that: ““We need to do everything we can to maintain optimal risk factors so that we reduce the chances of developing cardiovascular disease and increase the chances that we’ll live longer and healthier.”

Dr. Klatz observes: “In that many people develop cardiovascular disease as they live into old age, the lifetime risk for total cardiovascular disease may provide projections of future population burden of CVD. These researchers report that optimal heart health in middle age helps the odds of living up to 14 years longer, free of cardiovascular disease.”

Physical Activity Promotes Cognitive Health
Ana Verdelho, from the University of Lisbon (Portugal), and colleagues involved in the LADIS (Leukoaraiosis and Disability) Study studied 638 men and women, average age 74.1 years, of whom 64% were considered physically active at baseline. Baseline MRI revealed the severity of white matter changes categorized as mild and 44% of subjects, moderate and 31%, and severe 25%. Participants were given neuropsychological tests annually for three years. A second MRI brain scan was given at the study’s conclusion, to evaluate the severity of white matter changes. The team found that physical activity associated with less progression to cognitive impairment or vascular dementia. However, physical activity was not found to be related to changes in the risk of Alzheimer’s disease. The study authors conclude that: “Physical activity reduces the risk of cognitive impairment, mainly vascular dementia, in older people living independently.”

Remarks Dr. Goldman: “Previous studies have associated physical activity with lower risk of cognitive decline and progression to dementia. This team finds that older people who are living independently but have signs of cerebral damage may lower their risk of having progressive cognitive impairment or dementia if they remain physically active.”

Olive Oil Compound Exerts Anti-Cancer Effects
ZK Hassan, from King Saud University (Saudi Arabia), and colleagues investigated the effect of oleuropein on the metastatic and anti-metastatic gene expression in the MDA human breast cancer cell line. The team observed that oleuropein initially down-regulated matrix Metalloproteinase (MMP) genes – thought to be overexpressed in tumor cells; and oleuropein promoted the tissue inhibitors of metalloproteinases (TIMPS) – with which cell-death inducing properties are associated. The study authors submit that: “oleuropein plays an important role in regulating MDA cell metastasis by suppressing the expression of MMP-2 and MMP-9 genes and upregulating the expression of TIMP1 and TIMP4 genes in breast cancer cells therefore it can help in tailoring new anti-metastatic cancer therapy.”

Comments Dr. Klatz: “Olive oil contains oleuropein, a potent antioxidant compound, for which previous researchers have identified the capacity to inhibit cell proliferation of breast and urinary cancers, as well, as to decrease breast cancer cell viability. Oleuropein may induce anti-metastatic effects on human breast cancer cell lines, reports this group of researchers.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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