February 1-7, 2013
By Dr. Ronald Klatz & Dr. Robert Goldman
Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.
Safety of Daily Multivitamin Reaffirmed
H. Macpherson, from Swinburne University (Australia), and colleagues completed a meta-analysis of randomized controlled primary or secondary prevention trials that investigated daily multivitamin/multimineral supplementation for 1 year or longer. In total, 21 articles were included in the analysis, which generated a total pooled sample of 91,074 subjects (average age 62 years). The researchers observed that taking a daily multivitamin/multimineral supplement does not raise the risk of all-cause mortality, or mortality specifically from cancer or vascular causes. Further, the team found a trend for a reduced risk of all-cause mortality across primary prevention trials. The study authors conclude that: “multivitamin-multimineral treatment has no effect on mortality risk.”
Dr. Klatz observes: “Whereas multivitamins are the most commonly used supplement in the developed world, a number of recently published studies have differed regarding whether multivitamin/multimineral supplementation increases the risk of mortality. An extensive meta-analysis involving 91,000+ subjects reports that taking a daily multivitamin/multimineral supplement does not raise the risk of death.”
Longer Telomeres via Long-Term Endurance Exercise
Researchers from the Norwegian University of Science and Technology (Norway) report that endurance training may protect against the effects of aging in older individuals. Javaid Nauman and colleagues recruited 20 men, half of whom were ages 22 to 27 and the other half ages 66 to 77. In each age group, half of the participants were endurance athletes who were taking part in a cross-country ski race or track competitions. The others were nonathletes who were active, but who had never competed at higher levels in any sports. All of the participants were free from known cardiovascular disease, obesity, and a history of current or past smoking. None was taking regular medications. The team observed that in the older age group, the endurance athletes had significantly longer telomeres. Further, in the overall cohort, telomere length was positively associated with VO2max, with the relationship strongest among the endurance athletes. The study authors write that: “Our data suggest that VO2max is positively associated with telomere length, and we found that long-term endurance exercise training may provide a protective effect on muscle telomere length in older people.”
Remarks Dr. Goldman: “Telomeres are the end caps of chromosomes, protecting the DNA complexes from deterioration during cell division. Telomere shortening is considered a marker of cellular aging, and prematurely shortened telomeres have been linked to increased risk of cancers, heart disease, dementia and death. Norwegian researchers report that older athletes who engage in endurance training have longer telomere length, and maximal oxygen consumption positively associates with telomere length.”
Inflammation Linked with Poor Mental Health
Marie Kim Wium-Andersen, from Copenhagen University Hospital (Denmark), and colleagues analyzed CRP levels using data from two general population studies in Copenhagen, which included 73,131 men and women ages 20 to 100 years. Increasing CRP levels were associated with increasing risk for psychological distress and depression in analyses. Other analyses suggest that increasing CRP levels also were associated with increasing risk for hospitalization with depression, according to the study results. The study authors conclude that: “Elevated levels of [C-reactive protein] are associated with increased risk for psychological distress and depression in the general population.”
Comments Dr. Klatz: “C-reactive protein (CRP) is a commonly used marker of inflammation, and previous studies suggest that low-grade systemic inflammation may contribute to the development of mental health issues. Danish researchers reveal that elevated levels of C-reactive protein may associate with increased risk of psychological distress and depression.”
Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
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