March 22-28, 2013

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Olive Oil & Nuts Help to Reduce Heart Attack, Stroke Risks
Ramon Estruch, from Hospital Clinic (Spain), and colleagues enrolled 7,447 men and women, ages 55 to 80 years, who were free of cardiovascular disease at the study’s start but either had diabetes or at least three cardiovascular risk factors (smoking, high blood pressure, or obesity), to consume either a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). All subjects received quarterly individual and group educational sessions.  After a median follow-up of 4.8 years, 288 participants had a primary endpoint event, including 96 (3.8%) in the olive-oil group, 83 (3.4%) in the mixed-nut group, and 109 (4.4%) in the control group.  In a multivariable analysis, the olive-oil diet led to a 28% reduction in risk, compared with the control diet; with the mixed nut diet exerting similar risk reduction.  The study authors conclude that: “Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events.”

Dr. Klatz observes: “A Mediterranean-style diet – rich in olive oil, nuts, as w ell as fruits, vegetables, and legumes – may curtail the risks of heart attack, stroke, and cardiovascular-related death.”

The Merits of Movement
Emma S George, University of Western Sydney (Australia), and colleagues, reported on their analysis of data from subjects enrolled in Australia’s 45 and Up Study, involving more than 267,000 people and for which a subset of 63,048 men, ages 45 t0 65 years, was selected.  The team found that, compared with those who reported sitting four hours or less per day, those who sat for more than four hours per day were significantly more likely to report having a chronic disease such as cancer, diabetes, heart disease and high blood pressure. The reporting of chronic diseases rose as participants indicated they sat more. Those sitting for at least six hours were significantly more likely to report having diabetes.   The study authors conclude that: “Our findings suggest that higher volumes of sitting time are significantly associated with diabetes and overall chronic disease, independent of physical activity.”  Separate findings from Joseph Henson, from the University of Leicester (United Kingdom), and colleagues report that simply rising from the chair and moving a little may help ward off type 2 diabetes among individuals at risk even more than engaging in strenuous physical activity. The team found that time spent sedentary significantly correlated to negative metabolic factors including 2-hour glucose level, high-density lipoprotein (HDL) cholesterol, and triglycerides, writing that: “In adults at high risk of type 2 diabetes mellitus, time spent sedentary is strongly and adversely associated with cardiometabolic health and may be a more important indicator of poor health than [moderate-to-vigorous physical activity].”
Remarks Dr. Goldman: “With evidence mounting that suggests that the more a person sits, the greater his/her risk of chronic diseases, two studies reaffirm the merits of moving about. From Australia to Great Britain, researcher teams confirm that the more a person sits, the greater the risk of chronic diseases.”

Vitamin C May Help Reduce Incidence of Common Cold
Hemila Harri, from the University of Helsinki (Finland), and colleagues completed a meta-analysis of 29 clinical trials enrolling 11,306 subjects that involved Vitamin C and the common cold.  The team found that Vitamin C seems to be particularly beneficial for people under heavy physical stress. In five randomized trials of participants with heavy short-term physical stress, vitamin C halved the incidence of the common cold.  Further, in a recent randomized trial carried out with adolescent competitive swimmers, vitamin C halved the duration of colds in males (but had no effect among  female subjects).   Regular doses of vitamin C of one gram per day or higher have reduced the average duration of colds in adults by 8% and in children by 18%.  Writing that: “vitamin C may be useful for people exposed to brief periods of severe physical exercise,” the study authors submit that: “[due to its] low cost and safety, it may be worthwhile for common cold patients to test on an individual basis whether therapeutic vitamin C is beneficial for them.”

Comments Dr. Klatz: “Whereas Vitamin C gained much popularity from research by Nobel laureate Linus Pauling in the 1970s, data varies as to whether it can prevent and/or treat the common cold.   These researchers find that Vitamin C seems to be particularly beneficial for people under heavy physical stress, with data suggesting it  can halve the incidence of the common cold.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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