May 17-23, 2013

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Fiber Improves Metabolic & Cardiovascular Markers
Valesca Dall’Alba, from Universidade Federal do Rio Grande do Sul (Brazil), and colleagues enrolled 44 type-2 diabetics, average age 62 years, and randomly assigned each subject to one of two groups: an intervention group – who consumed a usual diet supplemented with an additional 10 grams per day of guar gum; or a control group who consumed a usual diet only.  After  six weeks, the fiber-supplemented group decreased glycated hemoglobin (HbA4c) by 0.31% and lowered trans fatty acid levels from 71 to 57 mg/L; their waist circumference dropped from 103.5 cm to 102.3 cm. The only change in the control group was a 0.9 cm reduction in waist circumference.  The study authors conclude that: “the addition of [soluble fiber] to the usual diet improved cardiovascular and metabolic profiles by reducing [waist circumference], [glycated hemoglobin], [urinary albumin excretion], and [serum trans-fatty acids].”

Dr. Klatz observes: “While a diet rich in fiber seems to protect against the Metabolic Syndrome, there is scarce information about the role of fiber intake in patients who have these conditions.  This team reports that daily supplements of soluble fiber help to improve metabolic and cardiovascular measures, among diabetics.”

Exercise May Reduce Breast Cancer Risk
Cher Dallal, from the US National Cancer Institute (Maryland, USA), and colleagues evaluated 540 Polish women, ages 40 to 74 years, who were enrolled as healthy control patients in the NCI Polish Breast Cancer Study. None of the patients was on hormone therapy. The women engaged in a range of physical activity. For seven days, they wore an accelerometer on their waist while awake, which measured overall activity. The women also collected 12-hour urine samples. The researchers measured the hormones estradiol and estrone, along with different estrogen breakdown products, in the urine; they found that physical activity was associated with lower levels of the main estrogens, and that activity also was associated with increased metabolism of some of the breakdown products.  Writing that: “Our findings with accelerometer-measured physical activity are consistent with prior studies reporting a reduction in estrogen levels with increased activity,” the study authors submit that: “our results suggest that increased physical activity may lower endogenous estrogens by increasing hydroxylation, and subsequent metabolism, of estrogens.”

Remarks Dr. Goldman: “Older women who are physically active have lower levels of estrogen and its breakdown products in their bodies, providing insights that may help explain why exercise may reduce breast cancer risk.  This study by US National Cancer Institute scientists elucidates clues as to how exercise may be protective.”

Black Tea Compounds Beneficial for Blood Pressure
While previous studies suggest that regular consumption of black tea may help to lower blood pressure level, Jonathan M Hodgson, from the  University of Western Australia (Australia), and colleagues investigated its effects on blood pressure variation.   The team enrolled 111 men and women with systolic blood pressure between 110 and 150 mmHg, assigning each subject to one of two groups:  the first group consumed three cups per day of black tea; and the second group received a flavonoid-free caffeine-matched (control) beverage.  After six months of consuming the respective beverages, the tea group displayed 10% lower rates of systolic and diastolic blood pressure variation during the nighttime. Writing that: “These findings indicate that a component of black tea solids, other than caffeine, can influence the rate of blood pressure variation during nighttime,” the study authors submit that: “small dietary changes have the potential to significantly influence the rate of blood pressure variation.”

Comments Dr. Klatz: “Black tea is green tea that has been fermented.  Not only rich in heart-healthy flavonoids, black tea may help to reduce variability in nighttime blood pressure.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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