May 31 – June 6, 2013

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Fruits & Veggies Help to Prevent Heart Failure
Susanne Rautiainen, from Harvard Medical School (Massachusetts, USA), and colleagues analyzed data collected from 33,713 women enrolled in the Swedish Mammography Cohort, ages 49 to 83 years.  The team surveyed dietary intakes and calculated the dietary total antioxidant capacity for each participant.  Over 11.3 years of follow-up, 884 cases of heart failure occurred.  The researchers found that those women with the highest average antioxidant capacities were 42% less likely to develop heart failure, as compared to women with the lowest capacities.  Observing that: “The total antioxidant capacity of diet, an estimate reflecting all antioxidants in diet, was associated with lower risk of heart failure,” the study authors conclude that: “These results indicate that a healthful diet high in antioxidants may help prevent heart failure.”

Dr. Klatz observes: “Colorful fruits and vegetables are abundant in antioxidants, compounds that may protect against cardiovascular disease by preventing lipid oxidation and endothelial damage – both of which can lead to atherosclerosis, and by preserving the nitric oxide  pool – which helps to reduce blood pressure. These researchers find that a diet rich in antioxidants may reduce a woman’s risk of heart failure by 42%.”

Vascular Status Predicts Cognitive Decline
The Edinburgh Type 2 Diabetes Study (ET2DS) Investigators research group studied 831 men and women, ages 60-75 years, who participated in two study waves.  The team found that suffering a stroke was significantly associated with estimated lifetime cognitive decline.  Certain subclinical markers of vascular disease – namely, N-terminal probrain natriuretic peptide (NT-proBNP), ankle-brachial index (ABI), and carotid intima-media thickness (cIMT) – also were associated with cognitive decline over a 4-year period.  Observing that: “Stroke and subclinical markers of cardiac stress and generalized atherosclerosis are associated with cognitive decline in older patients with type 2 diabetes,” the study authors submit that: “Further investigation into the potential use of subclinical vascular disease markers in predicting cognitive decline is warranted.”

Remarks Dr. Goldman: “Previous studies suggest that vascular disease may contribute to increased risk of accelerated cognitive decline in people with type 2 diabetes.  Scottish researchers report that stroke and subclinical markers of vascular disease may be predicative of those older patients with type 2 diabetes who may develop cognitive decline.”

“Beet” Blood Pressure
Amrita Ahluwalia, from The London Medical School (United Kingdom), and colleagues enrolled 8 women and 7 men with a systolic blood pressure between 140 to 159 mm Hg, who did not have other medical complications and were not taking blood pressure medication. The study participants drank 250 mL of beetroot juice or water containing a low amount of nitrate, and had their blood pressure monitored over the next 24 hours.  Compared with the placebo group, participants drinking beetroot juice had reduced systolic and diastolic blood pressure – the effect was most pronounced three to six hours after drinking the juice but still present even 24 hours later.  The study authors submit that: “Our observations … support the concept of dietary nitrate supplementation as an effective, but simple and inexpensive, antihypertensive strategy.”

Comments Dr. Klatz: “In the human body, nitric oxide widens blood vessels and aids blood flow.  Beetroot is rich in nitrates, which the body converts to nitrite and then to nitric oxide. This team finds that a cup of beetroot juice a day may help reduce blood pressure by as much as 10 mm Hg.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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