June 28-July 4, 2013

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Tart Cherries May Reduce Stroke Risk
E. Mitchell Seymour, from  the University of Michigan (Michigan, USA), and colleagues compared the effect of tart cherries and a  prescription drug that helps to regulate fat and glucose but for which long-term use can increase stroke risk.  Employing a model of stroke-prone rats which were put through various physical tests, such as walking on a tapered beam and climbing a ladder, the researchers found that compared to the drug, tart cherry intake significantly improved balance and coordination, and at the same time lowered blood pressure.  The study authors submit that: “intake of a physiologically-relevant amount of anthocyanins from tart cherry significantly reduced stroke-related phenotypes, was safer than [prescription drug], and may be a good preclinical model to explore the stroke-protective effects of an anthocyanin-rich diet.”

Dr. Klatz observes: “Montmorency tart cherries have been found to activate PPAR isoforms (peroxisome proliferator activating receptors) in many of the body’s tissues.  Studies suggest that anthocyanins – the pigments that give the fruit its red color – may be responsible for PPAR activation.   A cherry-rich diet may decrease stroke risk, suggests an animal study.”

Obesity Robs Men of Years of Life
Morten Schmidt, from Aarhus University Hospital (Denmark), and colleagues tracked the health of 6,500 Danish 22-year-old men for 33 years up to the age of 55. All of them had been born in 1955, and had registered with the Military Board for a fitness test to gauge their suitability for military service.  All potential conscripts in Denmark are subjected to a battery of psychological and physical tests, including weight. Most (83%; 5407) were within the normal range and 5% were underweight (353). One in 10 (639) were overweight and 1.5% (97) were obese (body mass index [BMI] of 30 or more).  Almost half of those classified as obese at the age of 22 were diagnosed with diabetes, high blood pressure, heart attack, stroke, blood clots in the legs or lungs, or had died before reaching the age of 55.  They were eight times as likely to get diabetes as their normal weight peers and four times as likely to get a potentially fatal blood clot (venous thromboembolism). They were also more than twice as likely to develop high blood pressure, have had a heart attack, or to have died.  Every unit increase in BMI corresponded to an increased heart attack rate of 5%, high blood pressure and blood clot rates of 10%, and an increased diabetes rate of 20%. In all, obese young men were three times as likely to get any of these serious conditions as their normal weight peers by middle age, conferring an absolute risk of almost 50% compared with only 20% among their normal weight peers.  Writing that: “obesity was strongly associated with adverse cardiometabolic events before 55 years of age,” the study authors warn that: “young obese men had an absolute risk increase for type 2 diabetes, cardiovascular morbidity or premature death of almost 30%.”

Remarks Dr. Goldman: “A number of previous studies suggest that obesity in adulthood poses a risk for diabetes and cardiovascular disease, and Danish researchers find that obesity in early adulthood strengthens that risk.”

Nuts for a Healthy Weight
Gemma Flores-Mateo, from the Institut Universitari d’Investigacio en Atencio Primaria Jordi Gol (Spain), and colleagues completed a neta-analysisis of data resulting from 31 worldwide studies and found not only that most of the studies don’t show that patients gain a significant amount of weight – but that nuts – as part of a healthy, balanced diet – can help to stabilize insulin and suppress hunger.  The study authors conclude that: “diets enriched with nuts did not increase body weight, body mass index, or waist circumference in controlled clinical trials.”

Comments Dr. Klatz: “A number of previous studies suggest an inverse association between the frequency of nut consumption and body mass index (BMI) and risk of obesity.   With the ability to stabilize insulin and suppress hunger, nuts – as part of a healthy, balanced diet – assist with weight management goals.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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