Sept. 27 – Oct. 3. 2013

By Dr. Ronald Klatz and Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Link Between Retirement Age and Alzheimer’s Risk
Carole Dufouil, from INSERM (France), and colleagues completed analysis of a French healthcare insurer’s records involving 430,000 pensioners as of December 2010, finding that for each year after age 60 at which a person retired, the risk of subsequently developing Alzheimer’s disease was lower by 3.2%.  After adjusting for certain other risk factors, individuals retiring at 65 were 14.6% less likely to develop Alzheimer’s disease than those retiring at 60 years of age.

Dr. Klatz observes:  “A growing body of evidence suggests clear health benefits of maintaining cognitive and social stimulation in seniors.  French researchers observe that retirees who stop working relatively late in life may be less likely to develop Alzheimer’s Disease.”

Watermelon Helps Soothe Aching Muscles
Martha P. Tarazona-Díaz, from the  Universidad Politecnica de Cartagena  (Spain), and colleagues administered 500 mL of natural watermelon juice (containing 1.17 g of l-Citrulline), enriched watermelon juice (4.83 g of l-Citrulline plus 1.17 g naturally occurring), or a control beverage, to seven healthy university-age sports science students (average age 22.7 years).  Whereas neither juice form improved pedaling cadence, heart rate, or perceived exertion, both juice forms reduced muscle soreness 24-hours post-exercise.  The study authors report that: “watermelon juices helped to reduce the recovery heart rate and muscle soreness after 24 h.”

Remarks Dr. Goldman: “l-Citrulline, an amino acid shown in previous studies to reduce muscle soreness, is found abundantly in watermelons, as well as certain squashes, cucumbers, and other melons.  These researchers observe that watermelon juice can relieve sore muscles.”

Omega-3s Aid in Cancer Battle
Zacharoula Nikolakopoulou, from the University of London (United Kingdom), and colleagues studied squamous-cell carcinoma (SCC), one of the major forms of skin cancer. In that squamous cells also occur in the lining of the digestive tract, lungs, and other areas of the body, oral squamous cell carcinomas (OSCC) are the sixth most common cancer worldwide.  In their experiments, the researchers grew cell cultures in the lab from several different cells lines to which they added fatty acids. The cell lines included both malignant oral and skin SCCs, along with pre-malignant cells and normal skin and oral cells. The team observed that omega-3 fatty acids induced cell death in malignant and pre-malignant cells at doses which did not affect normal cells, with the researchers positing the effect as partly due to an over-stimulation of epidermal growth factor, which triggered cell death.  The study authors submit that: “Our results show that, in part, [eicosapentaenoic acid] specifically inhibits.

Comments Dr. Klatz: “A number of studies suggest that long chain omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), inhibit cancer formation in vivo.  These researchers observe that EPA and DHA selectively inhibit growth and induce cell death in early and late-stage oral and skin cancers.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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