November 1-7, 2013

By Dr. Ronald Klatz and Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Beat Arthritis with Broccoli
Ian Clark, from the University of East Anglia (United Kingdom), and colleagues have shown that sulforaphane slows down the destruction of cartilage in joints associated with painful and often debilitating osteoarthritis. The researchers found that mice fed a diet rich in the compound had significantly less cartilage damage and osteoarthritis than those that were not.  The study also examined human cartilage cells and cow cartilage tissue, finding that sulforaphane blocks the enzymes that cause joint destruction by stopping a key molecule known to cause inflammation. Observing that: “A [sulforaphane]-rich diet decreases arthritis score in the [destabilisation of medial meniscus] murine model of osteoarthritis,” the study authors conclude that: “[Sulforaphane] inhibits the expression of key metalloproteinases implicated in osteoarthritis … and blocks inflammation at … to protect against cartilage destruction in vitro and in vivo.”

Dr. Klatz observes: “Cruciferous vegetables – such as broccoli, Brussels sprouts, and cabbage – are a rich source of sulforaphane, a compound for which previous studies suggest an anti-inflammatory effect.  These researchers report that sulforaphane may help to prevent or slow cartilage destruction.”

Brisk, Albeit Brief, Activity Beneficially Affects Weight
Jessie X. Fan, from the University of Utah (Utah, USA), and colleagues enrolled 2,202 women and 2,309 men, ages 18 to 64 years, who were free of impairments that otherwise compromise the ability tp walk, from the National Health and Nutrition Examination Survey (NHANES).  From 2003 to 2006, participants in the survey wore accelerometers for seven days, which captured data on their physical activity.  Researchers compared measurements of physical activity based on length of time and intensity. The study used body mass index (BMI), to measure weight status. A BMI between 18.5 and 24.9 is considered normal weight, whereas a BMI between 25 and 29.9 is overweight; and over 30 is obese.  Results show that for women, each daily minute spent in higher-intensity short bouts was related to a decrease of .07 BMI. In other words, each such minute offset the calorie equivalent of .41 pounds. This means that when comparing two women each 5-feet-5-inches tall, the woman who regularly adds a minute of brisk activity to her day will weigh nearly a half-pound less. Results were similar for men. Importantly for both, each daily minute of higher-intensity activity lowered the odds of obesity – 5% for women, and 2% for men. The study authors conclude that: “Our findings showed that for weight gain prevention, accumulated higher-intensity [physical activity] bouts of [less than] 10 minutes are highly beneficial, supporting the public health promotion message that ‘every minute counts.’”

Remarks Dr. Goldman: “The current physical activity guideline for Americans is to get at least 150 minutes of moderate to vigorous physical activity, a week, which can be accumulated in eight to 10 minute periods.  Higher-intensity activity, even in short bouts, can help win the battle against the bulge.”

Depression May Accelerate Cognitive Decline
Researchers from the University of Seattle (Washington, USA) assessed whether depression raises the risks of  cognitive impairment, among type-2 diabetics.  Mark Sullivan and colleagues completed a 40-month cohort study of 2,977 subjects enrolled in the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial.  Depressed patients showed consistently greater declines in cognitive function on three separate assessment tests, even after adjustment for confounding factors  Observing that: “Depression in patients with type 2 diabetes was associated with greater cognitive decline in all domains, across all treatment arms, and in all participant subgroups assessed,” the study authors submit that: “Future randomized trials will be necessary to determine if depression treatment can lower the risk of cognitive decline in patients with diabetes.”

Comments Dr. Klatz: “In that major depression occurs in up to 20% of diabetics and it has been shown to increase the risk for retinopathy and other microvascular complications, as well as macrovascular complications like heart attack and stroke  This team reveals that depression in patients with type 2 diabetes is a significant risk factor for dementia.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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