November 22-28, 2013

By Dr. Ronald Klatz and Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Society-Wide Benefits of Delaying Aging
Dana Goldman, from the University of Southern California (USC; California, USA), and colleagues submit that research to delay aging and the infirmities of old age would have better population health and economic returns, as compared to advances in individual fatal diseases such as cancer and heart disease.  Using the Future Elderly Model – a microsimulation of the future health and spending of older Americans – the researchers  compared optimistic “disease specific” scenarios with a hypothetical “delayed aging” scenario in terms of the scenarios’ impact on longevity, disability, and major entitlement program costs. The team found that delayed aging could increase life expectancy by an additional 2.2 years, most of which would be spent in good health, with the economic value of delayed aging estimated to be $7.1 trillion over fifty years. The study authors that:  “Overall, greater investment in research to delay aging appears to be a highly efficient way to forestall disease, extend healthy life, and improve public health.”

Dr. Klatz observes: “Delayed aging could increase life expectancy by an additional 2.2 years, most of which would be spent in good health.  These researchers observe that: ‘Recent scientific advances suggest that slowing the aging process (senescence) is now a realistic goal … Yet most medical research remains focused on combating individual diseases.’”

Physical Activity Linked to Reduced Breast Cancer
Results of a large new study by researchers at the American Cancer Society have added to mounting evidence suggesting that physical activity reduces breast cancer risk in postmenopausal women. Alpa Patel, Ph.D., and colleagues compared exercise and breast cancer status in 73,615 postmenopausal women taking part in in the CPS-II Nutrition Cohort study. Results showed that 9.2% women reported no recreational physical activity at the beginning of the study. Among those who said they were physically active, the average expenditure was equivalent to 3.5 hours per week of moderate walking. Among all the participants, 47% reported that walking was their only recreational activity. Physically active women tended to be leaner, more likely to maintain or lose weight during adulthood, more likely to drink alcohol, and less likely to currently smoke. They were also more likely to use postmenopausal hormone therapy and to have had a mammogram in the past year. Further analysis revealed that among those who reported walking as their only activity, those who walked for at least 7 hours per week had a 14% lower risk of breast cancer compared to those who walked 3 hours or less each week. Whilst the most active women had a 25% lower risk of breast cancer than the least active, a finding that is consistent with the majority of prior studies. Risk was not found to be linked to hormone receptor status, BMI, weight gain, postmenopausal hormone use, or sitting time. “Our results clearly support an association between physical activity and postmenopausal breast cancer, with more vigorous activity having a stronger effect,” said Dr. Patel. “Our findings are particularly relevant, as people struggle with conflicting information about how much activity they need to stay healthy. Without any other recreational physical activities, walking on average of at least 1 hour per day was associated with a modestly lower risk of breast cancer. More strenuous and longer activities lowered the risk even more.”

Remarks Dr. Goldman: “These researchers submit data to suggest that physical activity reduces the risk of breast cancer in postmenopausal women by as much as 25%.”

Red Grapes and Blueberries May Boost Immune System
Blueberries and red grapes contain compounds that researchers believe may help boost the immune system. Researchers in the Linus Pauling Institute at Oregon State University analyzed 446 compounds for their ability to boost the innate immune system in humans, however just 2 appeared to be effective – pterostilbene from blueberries and resveratrol from red grapes. The 2 compounds, which are both stilbenoids, were found to work in synergy with vitamin D to significantly increase the expression of the human cathelicidin antimicrobial peptide (CAMP) gene, which has been shown to play a key role in the innate immune system. Adrian Gombart, associate professor at Oregon State University College of Science, said: “Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It’s a pretty interesting interaction.” The researchers concluded: “Our findings demonstrate for the first time that stilbenoid compounds may have the potential to boost the innate immune response by increasing CAMP gene expression, particularly in combination with 1?,25(OH)2 D3 [vitamin D3].”

Comments Dr. Klatz: “ Compounds found in red grapes and blueberries are shown to increase the expression of a gene involved in immune function.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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