January 24-30, 2014

By Dr. Robert Goldman & Dr. Ronald Klatz

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

More Magnesium May Lower Death Risk
Spanish researchers completed a prospective study of subjects enrolled in the Prevention con Dieta Mediterranea (PREDIMED) study, in which participants at a high risk of cardiovascular risk were randomly assigned to consume a Mediterranean diet supplemented with nuts or olive oil, or a low-fat control diet.  Following the subjects for five years, the team found that those with the highest average intakes of magnesium (442 mg/day) were at 59% reduced risk of cardiovascular mortality, a 37% reduction in cancer mortality, and a 34% reduction in all-cause mortality, as compared to those with the lowest average intakes of magnesium (312 mg/day).  The study authors conclude that: “Dietary magnesium intake was inversely associated with mortality risk in Mediterranean individuals at high risk of [cardiovascular disease].”

Dr. Klatz observes:  “A growing body of evidence suggests that magnesium associates with heart health benefits, including to modulate blood pressure, inhibit platelet aggregation, and improve endothelial function. This Spanish team reports that an increased dietary intake of magnesium may reduce mortality, among people at high cardiovascular risk.”

Physical Fitness Preserves Thinking & Memory
Carrington R. Wendell, from the National Institute on Aging (Maryland, USA), and colleagues studied 1,400 men and women, ages 19 to 94 years, who were asked to walk, jog or run on a treadmill until they were out of breath. A machine measured the amount of oxygen participants breathed in and carbon dioxide breathed out, to yield each subject’s VO2 max – the maximal amount of oxygen used by the lungs during one minute of strenuous exercise.  The researchers followed each person for an average of seven years after the treadmill test. All participants took a memory test and followed up with the study team once, with fewer than half making a second visit to complete additional cognitive tests.  By mapping participants’ physical fitness against the number of errors they made on a range of cognitive tests over time, the team found that 80-year-olds who were at one point approximately twice as fit as their peers made about 25% fewer errors on a test of memory and concentration. Observing that: “Baseline cardiorespiratory fitness is related to longitudinal neuropsychological performance, and memory appears to be a particularly vulnerable domain,” the study authors conclude that: “Evidence that aerobic fitness is associated with accelerated cognitive decline emphasizes the possible importance of behavioral interventions to optimize cognitive aging over time.”

Remarks Dr. Goldman: “Previous studies have linked a lack of exercise with declines in thinking and memory with aging.  These researchers confirm such association, finding that men and women who are in good physical shape are more likely to retain cognitive skills as they age.”

Coffee Compounds Assist Heart Health
Japanese researchers enrolled a group of healthy, non-diabetic men in a study in which each was randomly assigned to consume = a 75 g glucose load either with or without green coffee bean polyphenols. The team observed that blood glucose and insulin levels increased after both interventions, and there were no differences between the groups. However, a marker of endothelial function known as the reactive hyperemia index rose significantly in the polyphenol group, as compared to their starting levels. The study authors conclude that: “These findings suggest that a single ingestion of [coffee polyphenols] improves peripheral endothelial function after glucose loading in healthy subjects.”

Comments Dr. Klatz: “The cells that line blood vessels, known as the endothelium, perform many functions including to maintain elasticity of blood vessels and regulate the activity of immune cells.  This study finds that tpolyphenols in coffee may improve the function of the cells lining blood vessels, among healthy men.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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