March 7-13, 2014

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Tree Nuts Reduce Heart Disease & Diabetes Risks
Joan Sabate, from Loma Linda University (California, USA), and colleagues analyzed the dietary habits of 803 adults enrolled in the Adventist Health Study-2.  The data revealed that those subjects who ate about 16 grams (half an ounce) per day – were only slightly over their normal weight, on average, compared to those who ate few or no nuts and were seriously overweight or obese.  As well, those who ate the most nuts had an average body mass index (BMI) of 27, as compared to those who ate the fewest (less than 5 grams daily) at an average BMI of 29-30.  Identifying that one-third of the study subjects had metabolic syndrome, which raises the risks of heart disease and diabetes risk, the team found that every one-ounce serving of tree nuts consumed per week, reduced that risk by 7%.  The study authors submit that: “Tree nuts appear to have strong inverse association with obesity, and favorable though weaker association with [Metabolic Syndrome] independent of demographic, lifestyle and dietary factors.”

Dr. Klatz observes: “Now known to be a good source of unsaturated (“good”) fat, and high in protein, tree nuts – which include pistachios, cashews, almonds, pecans and walnuts – may help people to manage their weight.  This study reveals that people who consume tree nuts may be less obese and have fewer risk factors for heart disease and diabetes.”

Fit 20s Fights Heart Disease in 50s
Peter Nordstrom, from Umea University (Sweden), and colleagues analyzed data collected on 743,498 Swedish men, examined during conscription in the military at an average age of 18.5 years. After adjusting for compounding factors, an increase of one standard deviation – or 15% – in the level of aerobic fitness at the age of 18 years associated with an 18% lower risk of heart attack (myocardial infarction) during follow-up. Men in the lowest one-fifth ranking of aerobic fitness were at approximately twice the risk of heart attack, as compared to men in the highest one-fifth rank.  Additionally, the team examined whether a high-level fitness could overcome the detrimental effects of obesity. They found that obese men who had the highest fitness level were still at an elevated risk of heart attack, as compared to the leanest men (body-mass index [BMI] under 18.5) at the lowest level of fitness.  The study authors warn of “a significant graded association between aerobic fitness in late adolescence and [myocardial infarction] later in life in men.”

Remarks Dr. Goldman: “Cardiovascular disease is the leading cause of death and incapacity worldwide.   Because signs of atherosclerosis can be present in a person’s large arteries as early as the adolescent years, being fit during the transition from the teenage years into adulthood may protect against heart disease decades later.”

New Hazardous Mechanism of Bisphenol A Identified
Raphael Stoll, from the Ruhr Universitat (Germany), and colleagues have discovered that BPA affects certain enzymes within the cells known as small GTPases, which are responsible for transmitting signals within the cell.  These enzymes normally occur in two states: the active form when bound to the GTP molecule; and the inactive form when bound to GDP – a lower-energy form of GTP.  These researchers have found that BPA binds to small GTPases, thereby preventing them from exchanging GDP for GTP – and suggesting a new mechanism of action of BPA.

Comments Dr. Klatz: “Bisphenol A (BPA) is a synthetic compound commonly found in plastics and the linings of food cans.  The chemical has been the focus of recent concerns as data suggests that BPA acts as an endocrine disruptor in the human body, alters the body’s hormonal balance by replicating the activity of naturally occurring estrogen.  This important study by German researchers identifies another health-related danger of BPA.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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