April 11-17, 2014

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Predicative Value of Blood Pressure
Norrina B. Allen, from Northwestern University (Illinois, USA), and colleagues completed a 25-year long study involving 4,681 men and women enrolled in the CARDIA study, ages 18 to 30 years at the study’s start.  The team followed systolic BP, diastolic BP, and mid-BP (important marker of coronary heart disease risk among younger populations) at the study’s start and years 2, 5, 7, 10, 15, 20, and 25.  Compared to participants with the best blood pressure profiles over the 25-year follow-up (low-stable group), those with the worst profiles (elevated-increasing blood pressure) were 3.7-times as likely to have a coronary artery calcification score of 100 HU or greater.  Observing that: “Blood pressure trajectories throughout young adulthood vary, and higher [blood pressure] trajectories were associated with an increased risk of [coronary artery calcification] in middle age.,” the study authors submit that: “Long-term trajectories in [blood pressure] may assist in more accurate identification of individuals with subclinical atherosclerosis.”

Dr. Klatz observes: “Current models to predict cardiovascular disease consider blood pressure (BP) at the time of prediction, rather than factoring in cumulative blood pressure over time.  As an alternative approach, these researchers propose that blood pressure trending towards rising numbers in young adulthood may presage coronary artery calcification in middle-age.”

Exercise Trumps Drugs in 3 Common Health Conditions
John Ioannidis, from Tufts School of Medicine (Massachusetts, USA), and colleagues completed a large-scale meta-analysis of data collected on a total of 339,274 subjects involved in 305 randomized control trials.  Only in one specific aspect of cardiovascular disease – heart failure – were prescription drugs found to be clearly more beneficial than exercise.   The study authors report that: “evidence on exercise interventions suggests that exercise and many drug interventions are often potentially similar in terms of their mortality benefits in the secondary prevention of coronary heart disease, rehabilitation after stroke  … and prevention of diabetes.”

Remarks Dr. Goldman: “Adding to an ever-growing stockpile of evidence demonstrating the wide-ranging health benefits of exercise, this large-scale meta-analysis reveals that routine physical activity may be as effective than prescription drugs, for coronary heart disease, diabetes, and stroke.”

Modern-Day Conveniences Contribute to Obesity
Scott Lear, from Simon Fraser University (Canada), and colleagues analyzed data collected on 153,996 adults residing in high, upper-middle, lower-middle and low income countries. Questioning participants about ownership of modern-day devices, as well as physical activity and diet, the researchers observed a 400% increase in obesity and a 250% increase in diabetes, among residents in low-income countries who owned televisions, computers, and cars. Further, the study also showed that owning all three devices was associated with a 31% decrease in physical activity, 21% increase in sitting and a   increase in waist size, as compared with those who owned no devices.  Interestingly, the team found no association in high-income countries, suggesting that the effects of owning items linked to sedimentary lifestyles has already occurred, and is reflected in current high rates of these conditions. The study authors warn that:  “The ownership of household devices increased the likelihood of obesity and diabetes, and this was mediated in part by effects on physical activity, sitting time and dietary energy intake. With increasing ownership of household devices in developing countries, societal interventions are needed to mitigate their effects on poor health.”

Comments Dr. Klatz: “Televisions, computers, and cars are rapidly becoming more available in developing countries. As a consequence, an international study involving 17 countries reports that people who own televisions, computers, and cars appear to be at higher risk for obesity and diabetes, among residents of developing countries.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
Visit the A4M’s World Health Network website, at www.worldhealth.net, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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