May 22-23, 2014

By Dr. Ronald Klatz & Dr. Robert Goldman

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Fish Protects the Heart
Akira Sekikawa, from the University of Pittsburgh Graduate School of Public Health (Pennsylvania, USA), and colleagues followed 266 men, ages 40-49 years at the study’s start, for five years, tracking multiple factors that affect cardiovascular health, including cigarette smoking, the level of cholesterol in the blood and alcohol consumption, as well as their rates of diabetes and high blood pressure. Middle-aged Japanese men living in Japan had lower incidence of coronary artery calcification, a predictor of heart disease, than middle-aged white men living in the United States.  After accounting for risk factors for heart disease, the U.S. men had three times the incidence of coronary artery calcification as the Japanese men. As well, the levels of marine-derived omega-3 fatty acid in the blood were more than 100% higher in the Japanese than in the white men. The study authors report that: “[Long chain omega-3 polyunsaturated fatty acids] significantly contributed to the difference in the incidence of [coronary artery calcification] between Japanese and white men.”

Dr. Klatz observes: “Eating fish in amounts comparable to those of people living in Japan seems to impart a protective factor that wards off heart disease.  These researchers find that consuming 100 grams (3.5 ounces) of fish every day may reduce coronary artery calcification.”

BMI Linked to Diabetes, High Blood Pressure
Michael V. Holmes, from the University of Pennsylvania (Pennsylvania, USA), and colleagues have found that for every 1 kg/m2 increase in body mass index (BMI), the risk of developing type 2 diabetes increases by 27%. The same rise in BMI also increases blood pressure by 0.7 mmHg. Of their study involving data collected on 87.736 individuals, the study authors submit that: “Our findings extend our understanding of genes involved in [blood pressure] regulation, which may provide new targets for therapeutic intervention.”

Remarks Dr. Goldman: “A recently developed statistical tool called Mendelian randomization (MR) has enabled an international team to complete a large-scale genetic analysis to reveal a genetic basis for Type-2 diabetes and hypertension (high blood pressure).   Data resultant from this large-scale genetic analysis reports a direct causal link between body mass index (BMI) and Type-2 diabetes and hypertension.”

Omega-3s Help to Manage BP
Dominik D. Alexander, from the Center for Epidemiology, Biostatistics, and Computational Biology at Exponent, Inc. (Illinois, USA), completed a large-s ale meta-analysis involving 70 randomized  controlled trials (RCTs) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for blood pressure management.  The team found that consumption of EPA and DHA reduced systolic blood pressure by an average of 1.52 mmHg, and lowered diastolic blood pressure by 0.99 mmHg, as compared to subjects on placebo.   Noting that: “the strongest effects of EPA+DHA were observed among untreated hypertensive subjects,” the study authors conclude that: “available evidence from [randomized  controlled trials] indicates that provision of [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)]  reduces systolic blood pressure, while provision of [more than] 2 grams reduces diastolic blood pressure.”

Comments Dr. Klatz: “A major risk factor for heart disease and stroke, hypertension (high blood pressure) can be managed by a number of non-drug approaches. This meta-analysis reports that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) helps to reduce high blood pressure.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.  Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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