August 15-21, 2014

By Dr. Robert Goldman & Dr. Ronald Klatz

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Purpose In Life Adds Years to Life
Patrick Hill from Carleton University (Canada), and colleagues utilized data collected on over 6,000 subjects enrolled in the Midlife in the United States (MIDUS) study.  Over the 14-year follow-up period, 569 of the participants had died (about 9% of the sample). Those who had died had reported lower purpose in life and fewer positive relations than did survivors.  Greater purpose in life consistently predicted lower mortality risk across the lifespan, showing the same benefit for younger, middle-aged, and older participants across the follow-up period.  The study authors submit that: “having a purpose in life appears to widely buffer against mortality risk across the adult years.”

Dr. Klatz observes: “A number of previous studies have suggested that finding a purpose in life lowers risk of mortality above and beyond other factors that are known to predict longevity. These Canadian researchers submit that setting a direction and goals for what you wish to achieve may help you live longer.”

Poor Fitness in Midlife May Raise Heart Failure Risk
Stephanie K. Brinker, from the University of Texas Southwestern Medical Center (Texas, USA), and colleagues explored the mechanism through which fitness lowers heart failure risk.  The team assessed fitness in 1,678 men and 1,247 women enrolled in the Cooper Center Longitudinal Study.  Participants received an echocardiogram from 1999 to 2011 and were categorized into age-specific quartiles of fitness, with quartile 1 representing low fitness.  The researchers found that higher levels of mid-life fitness (metabolic equivalents) correlated with larger indexed left atrial volume and indexed left ventricular end-diastolic diameter. There was also a correlation for higher level of fitness with a smaller relative wall thickness and E/e’ ratio. Writing that: “low fitness is associated with a higher prevalence of concentric remodeling and diastolic dysfunction,” the study authors submit that: “exercise may lower heart failure risk through its effect on favorable cardiac remodeling and improved diastolic function.”

Remarks Dr. Goldman: “Cardiorespiratory fitness is inversely associated with heart failure risk. This team reports that low cardiorespiratory fitness increases the prevalence of concentric remodeling and diastolic dysfunction.”

Grapes May Alleviate Arthritis
Shanil Juma, from Texas Woman’s University (Texas, USA), and colleagues conducted a sixteen week clinical study, in which 72 men and women with knee osteoarthritis were assigned to either consume grapes in the form of a whole grape freeze-dried powder, or a placebo powder.  The data revealed that both men and women consuming a grape-enriched diet had a significant decrease in self-reported pain related to activity and an overall decrease in total knee symptoms – notably, improved joint flexibility and overall mobility. This beneficial effect was more pronounced in females. Additionally, age-related differences were observed: there was a 70% increase in very hard activity for those under 64 years of age consuming the grape powder, while those receiving the placebo reported a significant decrease in very hard activity.  Attributing these observed benefits to the polyphenols found in grapes, the lead investigator comments that: “These findings provide promising data that links grape consumption to two very important outcomes for those living with knee osteoarthritis: reduced pain and improvements in joint flexibility.”

Comments Dr. Klatz:  “Grapes are rich in anti-inflammatory polyphenols, compounds that have been shown to reduce inflammation. This study suggests that consuming grapes may confer benefits for knee osteoarthritis.”
Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.  Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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