August 22-28, 2014

By Dr. Robert Goldman & Dr. Ronald Klatz

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Heart Benefits of Lifelong Healthy Weight
John Deanfield from University College London (United Kingdom), and colleagues analyzed data on the majority of living subjects residing locally, enrolled in The National Survey of Health and Development Study, which originally involved 5.362 singleton births of married parents in England, Scotland, and Wales, during 1 week in March 1946.  The data revealed that the longer the exposure to excess body fat (adiposity) in adulthood the greater the cardiovascular-related problems in later life, including increased thickness of the carotid artery walls, raised systolic blood pressure, and increased risk of diabetes.  Importantly, the findings also indicate that adults who drop a BMI category – from obese to overweight, or from overweight to normal – at any time during adult life, even if they regain weight, can reduce these cardiovascular manifestations. The study authors urge that: “weight loss, at any age in adulthood, is worthwhile because it might result in long-term cardiovascular benefit.”

Dr. Klatz observes: “A number of previous studies suggest that excess body fat raises a person’s risk of diseases ranging from type-2 diabetes to hypertension. This study confirms that maintaining a healthy weight at any age in adulthood may confer long-term cardiovascular benefits.”

Enjoy This “Snack” Before a Meal    
Monique E. Francois, from the University of Otago (New Zealand), and colleagues studied two women and seven men diagnosed with insulin resistance. Two of the participants had type 2 diabetes, but none were taking medication for diabetes or blood sugar control. The participants completed three separate one-day exercise programs in a random order. The exercise snacks program involved short bouts of intense exercise on a treadmill before breakfast, lunch and dinner. The composite exercise snacks regimen was similar, but included some resistance exercises alternating with walking. The traditional continuous exercise program consisted of 30 minutes of moderate-intensity walking before dinner only. Meal timing and composition were the same during the three days. The researchers found that the exercise snacks and composite exercise snacks routines controlled blood sugar more effectively than the continuous exercise routine. Specifically, there was a 17% reduction in glucose levels over the three hours following breakfast and a 13% reduction in glucose levels after dinner on the exercise snack days compared to the continuous exercise days.  Across the day this represented a 12% reduction in average post-meal blood glucose levels.  The study authors conclude that: “Dosing exercise as brief, intense ‘exercise snacks’ before main meals is a time-efficient and effective approach to improve glycaemic control in individuals with insulin resistance.”

Remarks Dr. Goldman: “Lifestyle – and particularly, routine physical activity – is linked to blood sugar control, among people with insulin resistance (a precursor to diabetes).  New Zealand researchers find that a short burst of intense exercise, dubbed an “exercise snack,” before a meal may help control blood sugar spikes.”

Olive Oil May Counter Cardiac Effects of Air Pollution
Haiyan Tong, from the US Environmental Protection Agency (North Carolina, USA), and colleagues enrolled 42 healthy adults in a month-long study in which each received either 3 gram/day of olive oil, fish oil, or no supplements for 4 weeks before undergoing controlled 2-hour exposures to filtered air, followed on the next day by exposure to fine/ultrafine concentrated ambient particulate matter in a controlled-exposure chamber.  The team assessed endothelial function by sonographic measurement of flow-mediated dilation of the brachial artery before, immediately after, and 20 hours after exposure to air and the concentrated particulate matter.  They also measure blood markers of vasoconstriction and fibrinolysis.  Immediately after exposure to the concentrated particulate matter air, significant particulate matter mass-dependent reductions in flow-mediated dilation were observed in the control and fish oil groups, while the decrease in the olive oil group was not significant.  Further, tissue plasminogen activator, a protein involved in the breakdown of blood clots, increased immediately after concentrated particulate matter air exposure in the olive oil group, and this effect persisted up to 20 hours. Olive oil supplementation also ameliorated changes in blood markers associated with vasoconstriction and fibrinolysis, while fish oil supplementation had no effect on endothelial function or fibrinolysis after exposure to concentrated particulate matter air.  The study authors submit that: “These data suggest that [olive oil] supplementation may offer protection against the adverse vascular effects of exposure to air pollution particles.”

Comments Dr. Klatz:  “Rich in monounsaturated fatty acids, olive oil is a staple of the Mediterranean diet – with which a number of cardiovascular benefits are associated.  This study suggests that consuming olive oil may help to reduce endothelial dysfunction, which is a risk factor for cardiovascular disease.”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.  Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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