Aug. 29-Sep. 4, 2014

By Dr. Robert Goldman & Dr. Ronald Klatz

Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan.  These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M;, a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.   Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.

Crocus, The Anti-Cancer Flower
Saffron has been long-used as a folk medicine.  Scientists have identified that saffron contains vitamin B2 along with a yellow flavonoid called crocin, a bitter glycoside called picrocrocin, and the volatile, aromatic substance safranal. Korean researchers revealed that Crocetin showed approximately 5- to 18-fold higher cytotoxicity than crocin, a carboxylic carotenoid in saffron.  Importantly, the team found that both crocetin and crocin reduced the protein expression of lactate dehydrogenase A (LDHA), one of the targets for chemoprevention in cancer cells, by 34.2% and 10.5%, respectively.

Dr. Klatz observes: “Saffron is a spice derived from the flower of Crocus sativus, commonly known as the saffron crocus.  Laboratory analysis reveals that the saffron crocus is source to two potent cancer-fighting compounds.”

Cap Off a Swim with Chocolate Milk
A glass of chocolate milk after a hard swim could give swimmers a performance edge, report Indiana University researchers. Joel Stager and colleagues observe that when collegiate, trained swimmers recovered with chocolate milk after an exhaustive swim, they swam faster in time trials later that same day. On average, they shaved off 2.1 seconds per 200 yard swim, and 0.5 seconds per 75 yard sprint, compared to when they recovered with a traditional carbohydrate sports drink or calorie-free beverage.  With a unique carb to protein ratio, and fluids and electrolytes to help replenish the body, there are over 20 studies support the benefits of recovering with chocolate milk after a tough workout.
Remarks Dr. Goldman: “Not only did collegiate-trained swimmers recover better with chocolate milk after an exhaustive swim, they swam faster in time trials later that same day. Chocolate milk may be an accessible and economical post-exercise food.”

 Lack of Sleep Compromises the Brain
Jurgen Claassen, from Radboud University Medical Center (The Netherlands), and colleagues enrolled 26 middle-aged men with normal sleep habits to have their protein levels measured before and after sleep, or a lack of it.  In a monitored clinic setting, half of the men were randomly assigned to sleep the night, while the other half were kept awake.  The researchers found that the men who got a good night’s sleep had amyloid-beta levels in their spinal fluid about 6%  lower in the morning, as compared to when they had gone to bed. The men who were kept awake all night had no change in their amyloid-beta levels.  The quality of sleep men got was also linked to how much of a decrease in amyloid-beta was measured.  The study authors submit that: “Sleep deprivation, or prolonged wakefulness, interferes with a physiological morning decrease in [amyloid-beta protein]. We hypothesize that chronic sleep deprivation increases cerebral [amyloid-beta protein] levels, which elevates the risk of Alzheimer disease.”

Comments Dr. Klatz:  “A defining characteristic of Alzheimer’s Disease is an accumulation in the brain of the amyloid-beta protein. These researchers observe that after a night of no sleep, even a healthy brain has elevated levels of amyloid-beta”

Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases.  It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans.  As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties.  The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.  Visit the A4M’s World Health Network website, at, to learn more about the A4M and its educational endeavors and to sign-up for your free subscription o Longevity Magazine™ e-Journal.

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