By Dr. Ronald Klatz & Dr. Robert Goldman
Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.
Omega-3s May Postpone Metabolic Disorders
Inger Bjorck, from Lund University (Sweden), and colleagues enrolled 40 healthy middle-aged men and women in a study in which subjects consumed a daily supplement containing 3g of omega-3 fish oil, or placebo, for five weeks prior to the administration of standardized cognitive tests and collection of metabolic risk markers including blood pressure, serum triglycerides, and fasting glucose. The team observed that the subjects who consumed the omega-3 performed better on the cognitive assessments, and had lower systolic blood pressure, triglycerides, fasting glucose, and s-TNF-alpha (a marker of inflammation), which the study authors submit as “indicating a potential of+ dietary prevention strategies to delay onset of metabolic disorders and associated cognitive decline.”
Dr. Klatz observes: “Previously, studies have reported that higher plasma omega-3 polyunsaturated fatty acids (PUFA) associate with a lower risk of age related cognitive decline, and exert beneficial effects on cardiometabolic risk factors. These Swedish researchers report that supplementation with omega-3 fatty acids may postpone the onset of metabolic disorders and associated declines in cognitive functions.”
Weight Reduction May Reverse Diabetes
Edward Gregg, from the US Centers for Disease Control & Prevention (CDC; Georgia, USA), and colleagues investigated the outcomes of a four-year long intensive weight-loss intervention program on the frequency of remission from diabetes to prediabetes or normoglycemia in 2,241 subjects ages 45 to 75 years old with a median time since diabetes diagnosis of 5 years, and were “notably obese at baseline,” comparing them with a sample of 2,262 diabetes patients participating in a diabetes and support education intervention. The intensive weight-loss intervention included weekly group and individual counseling for the first 6 months focused on reducing caloric intake, decreasing consumption of total and saturated fats, and increasing physical activities; this was followed by three sessions per month for the second 6 months and twice-monthly sessions over years 2 to 4. Participants also were offered liquid meal replacements to help with dietary goals. In the support education intervention participants were given three group sessions annually that offered information on diet, physical activity, and social support. Participants in each group were evaluated at baseline and once at each year of the 4 years of follow-up for health status, including body mass index and glycemic status. Participant fitness also was assessed at baseline through a maximal graded exercise test and at years one and four through a submaximal exercise test. The researchers found that in addition to losing more weight, the weight-loss intervention group had greater increases in fitness in years 1 and 4 (20.6% versus 4.9% and 5.3% versus 1.5%, respectively) than those in the education group. Complete remission – defined as glucose normalization without medication – was more common among the lifestyle weight-loss participants than the education group (prevalence ratio 6.6), with participants significantly more likely to experience either partial or complete remission in the lifestyle intervention than in the education intervention at years 1 and 4. Return to clinical diabetes status occurred in roughly one-third of the lifestyle intervention group each year (33.1% at year 2, 33.8% at year 3, and 31.6% at year 4) versus around half among participants in the education group (52.4% at year 2, 45.9% at year 3, and 43.8% at year 4). In addition, continuous, sustained remission was significantly more common among weight-loss intervention participants than in the education group at years 2 to 4. The study authors conclude that: “In these exploratory analyses of overweight adults, an intensive lifestyle intervention was associated with a greater likelihood of partial remission of type 2 diabetes compared with diabetes support and education.”
Remarks Dr. Goldman: “Rates of type-2 diabetes are on the rise, in large part due to the obesity epidemic and rising numbers of the aging population. This important study reveals that intensive lifestyle-based weight-loss interventions associate with a partial remission of diabetes.”
B Vitamin for Bone Health
Z Dai, from National University of Singapore (Singapore), and colleagues analyzed data from 63,257 men and women, ages 45 to 74 years, enrolled in the Singapore Chinese Health Study. The researchers found that those women with the highest quartile intake of Vitamin B6 (0.78-1.76 mg/1,000 kcal/day) had a 22 % reduction in hip fracture risk, as compared to women in the lowest quartile intake (0.37-0.61 mg/1,000 kcal/day). Dietary intakes of the other B vitamins of interest were not related to hip fracture risk; and no correlative effects were seen in men. The study authors conclude that: “Our findings suggest that maintaining adequate intake of pyridoxine may prevent osteoporotic fractures among elderly women.”
Comments Dr. Klatz: “In that previous studies have investigated the role of B vitamins to maintain bone health, a Singaporean team finds that higher dietary intake of pyridoxine (Vitamin B6) associates with reduced risk of hip fracture, among women.”
Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
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