By Dr. Ronald Klatz & Dr. Robert Goldman
Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.
Olive Oil Nourishes Brain Cells
Amal Kaddoumi, from the University of Louisiana (Louisiana, USA), and colleagues completed in vitro and in vivo studies that demonstrate the ability for oleocanthal to two proteins- P-glycoprotein (P-gp) and LDL lipoprotein receptor related protein-1 (LRP1) – as well as key enzymes believed to be critical in removing beta-amyloid from the brain. The study investigators conclude that: “these findings provide experimental support that potential reduced risk of AD associated with extra-virgin olive oil could be mediated by enhancement of [beta-amyloid] clearance from the brain.”
Dr. Klatz observes: “Oleocanthal is a phenolic component found abundantly in extra-virgin olive oil; for which previous studies suggest that the compound may exert neuroprotective effects. Oleocanthal, a compound in olive oil, protects nerve cells from the insults that typify Alzheimer’s Disease – namely the accumulation of beta-amyloid and tau proteins in the brain.”
“D”fend Your Muscles
Among 12 men and women with Vitamin DS deficiency, Sinha Akash, from Newcastle University (United Kingdom), and colleagues investigated phosphocreatine recovery, a marker of muscle fatigue, both priot to and after Vitamin D supplementation. The team found that a 10- to 12-week period of dietary supplementation of Vitamin D significantly improved muscle phosphocreatine recovery. Further, all study subjects reported improvement in symptoms of fatigue. The study authors write that: “[Vitamin D] therapy augments muscle mitochondrial maximal oxidative phosphorylation following exercise in symptomatic, vitamin D deficient individuals,” submitting that: “For the first time, we demonstrate a link between vitamin D and the mitochondria in human skeletal muscle.”
Remarks Dr. Goldman: “Previously, research suggests that Vitamin D may assist in reducing muscle and joint pain in cancer patients, as well as improve muscle performance in overweight people. This research shows that dietary supplementation of Vitamin D may help to lessen muscle fatigue and improve efficiency, among people with low blood levels of the vitamin.”
Aspirin May Reduce Melanoma Risk
Jean Tang, from Stanford University (California, USA), and colleagues studied the use of NSAIDs and melanoma – the deadliest form of skin cancer. The team assessed data collected from 59,806 postmenopausal Caucasian women, ages 50 to 79 years, enrolled in the Women’s Health Initiative. The subjects were surveyed for their use of aspirin and nonaspirin NSAIDs and followed for a median period of 12 years to identify the development of melanomas. The researchers found that women who used aspirin were at 21% lower risk of melanoma, as compared to non-aspirin users. Further, each incremental increase in duration of aspirin use (less than one year of use, 1 to 4 years of use, and five or more years of use) correlated with an 11% lower risk of melanoma. Thus, women who used aspirin for five or more years were at 30% lower melanoma risk, as compared to women who did not take aspirin. Submitting that “aspirin works by reducing inflammation,” the study authors conclude that: “ Postmenopausal women who used [aspirin] had a significantly lower risk of melanoma, and longer duration of [aspirin] use was associated with greater protection.”
Comments Dr. Klatz: “Previous studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, associate with decreased risk of gastric, colorectal, and breast cancers. These researchers report that women who take aspirin are at a reduced risk of developing melanoma.”
Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
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