By Dr. Ronald Klatz & Dr. Robert Goldman
Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.
Sugar Excess May Damage Heart
Heinrich Taegtmeyer, from The University of Texas Health Science Center at Houston (Texas, USA). and colleagues report that a single small molecule, the glucose metabolite glucose 6-phosphate (G6P), causes stress to the heart that changes the muscle proteins and induces poor pump function leading to heart failure, as demonstrated by an animal model as well in tissue taken from patients at the Texas Heart Institute. In that G6P can accumulate from eating too much starch and/or sugar, the study authors “implicate a critical role for G6P in load-induced mTOR activation and [endoplasmic reticulum] stress,” proposing that: “glucose metabolic changes precede and regulate functional (and possibly also structural) remodeling of the heart.”
Dr. Klatz observes: “These researchers reveal that, in heart muscle that is stressed by hypertension or other diseases, sugar overload may promote heart failure.”
Health Hazards of Stress
Dominique Hange, from the University of Gothenburg (Sweden), and colleagues assessed data collected on 1,500 middle-aged women enrolled in the Population Study of Women in Gothenburg. The data revealed that one in five middle-aged women had experienced constant or frequent stress during the last five years. Further, in four out of ten cases, long-term stress suffered by women leads to some form of physical complaint. Among those women who reported stress, 40% had psychosomatic symptoms in the form of aches and pain in their muscles and joints, 28% suffered from headaches or migraines, and the same proportion reported gastrointestinal complaints. However, there was no association between perceived mental stress at baseline and mortality over 37 years of follow-up.
Remarks Dr. Goldman: “Mental distress is suspected as an underlying and often underrecognized cause of physical complaint. In four out of ten cases, long-term psychological stress leads to some form of physical ailment, among middle-aged women.“
Cocoa Combats Inflammation
Joshua D. Lambert, from Penn State (Pennsylvania, USA), and colleagues investigated effect of cocoa powder supplementation on obesity-related inflammation in high fat-fed obese mice. Mice that were fed cocoa with a high-fat diet experienced less obesity-related inflammation than mice fed the same high-fat diet without the supplement, said Joshua Lambert, associate professor of food science. The mice ate the human equivalent of 10 tablespoons of cocoa powder – about four or five cups of hot cocoa – during a 10-week period. The researchers reported that several indicators of inflammation and diabetes in the mice that were fed the cocoa supplement were much lower than the mice that were fed the high-fat diet without the cocoa powder and almost identical to the ones found that were fed a low-fat diet in the control group. For example, they had about 27% lower plasma insulin levels than the mice that were not fed cocoa. Further, the cocoa powder supplement also reduced the levels of liver triglycerides in mice by a little more than 32%. The study authors write that: “Dietary supplementation with cocoa ameliorates obesity-related inflammation, insulin resistance, and fatty liver disease … principally through the down-regulation of pro-inflammatory gene expression in WAT. These effects appear to be mediated in part by a modulation of dietary fat absorption and inhibition of macrophage infiltration in [white adipose tissue].”
Comments Dr. Klatz: “Cocoa powder is low in fat, low in sugar, and abundant in polyphenolic compounds – antioxidants also found in green tea and red wine. A cup of hot cocoa may help to control inflammation-related diseases such as diabetes, suggests an animal study.”
Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
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