By Dr. Ronald Klatz and Dr. Robert Goldman
Longevity News and Review provides readers with the latest information in breakthroughs pertaining to the extension of the healthy human lifespan. These news summaries are compiled by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), a non-profit medical society composed of 24,000 physician and scientist members from 110 nations, united in a mission to advance biomedical technologies to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. Dr. Ronald Klatz, M.D., D.O., A4M President, and Dr. Robert Goldman, M.D., Ph.D., D.O., FAASP, A4M Chairman, physician co-founders of the anti-aging medical movement, distill these headlines and provide their insightful commentary.
Sugar Feeds Cancers
Ross L. Cagan, from the Ichan School of Medicine at Mount Sinai (New York, USA), and colleagues have demonstrated that sugar activates oncogenes in the tumor, and also promoted tumor cell-specific insulin sensitivity by increasing the activity of the canonical signaling pathway (using a fruit fly model). The study authors submit that this feed-forward circuit may be targeted with “rationally applied drug combinations, we demonstrate the potential of combinatorial drug intervention to treat diet-enhanced malignant tumors.”
Dr. Klatz observes: “Previously, scientists have observed that people with Metabolic Syndrome – a condition characterized by central obesity, hypertension, and adverse glucose and insulin metabolism – are at an increased risk for certain cancers. This team observes that sugar consumption fuels tumor growth, potentially explaining why people with Metabolic Syndrome are at risk for certain cancers.”
Interval Training Boosts Women’s Health
Whereas numerous interval training studies have focused primarily on men, C. Matthew Laurent, of Bowling Green University (Ohio, USA), and colleagues compared the exercise modality to ascertain differences in benefits between men and women. The researchers put eight men and eight women, ages 19 to 30 years, through self-paced, high intensity interval training using different recovery periods. All of them reported at least a moderate fitness level and participation in at least one session of interval training a week. Participants hit the treadmill for six, four-minute intervals performed at the highest intensity they felt they could maintain. Recovery between intervals consisted of one minute, two minutes or four minutes. Throughout the intervals, their maximum oxygen consumption and heart rates were measured. Results revealed a significant effect of gender on both percentages. Across the trials, men self-selected a faster relative pace, but the women worked at a higher percentage of their maximum heart rate than the men and a higher percentage of their maximum oxygen consumption. The study authors observe that: “women may demonstrate improved recovery during high-intensity exercise, as they will self-select intensities resulting in greater cardiovascular strain.”
Remarks Dr. Goldman: “An enhanced form of interval training, an exercise strategy alternating periods of short intense anaerobic exercise with less-intense recovery periods, high-intensity interval training (HIIT) provides cardiovascular benefits, among women.”
Garlic May Protect Against Lung Cancer
Zi-Yi Jin, from the Jiangsu Provincial Center for Disease Control and Prevention (China), and colleagues interviewed 1,424 lung cancer patients, as well as 4,543 healthy control subjects, to ascertain lifestyle behaviors (particularly, if they smoked) and dietary habits (particularly, how much garlic they ate). The data revealed that consuming raw garlic may reduce lung cancer risk by as much as 44%. Among smokers, eating raw garlic 2-3 times a week may reduce lung cancer risk by as much as 30%. Noting a “protective association between intake of raw garlic and lung cancer,” the study authors conclude that: “garlic may potentially serve as a chemopreventive agent for lung cancer.”
Comments Dr. Klatz: “In that a number of previous studies report a protective effect of garlic, in both in vitro and in vivo experimental studies of cancer, Chinese researchers report that consuming raw garlic may reduce lung cancer risk by as much as 44%.”
Anti-aging medicine is the fastest-growing medical specialty throughout the world and is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on solid scientific principles of responsible medical care that are consistent with those applied in other preventive health specialties. The goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion.
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